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Apomorphine and morphine stimulate prostaglandin biosynthesis

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Abstract

AMONG the acute pharmacological effects of apomorphine and morphine are emesis, hyperthermia and hyperglycaemia1,2. Because administration of prostaglandins also elicits each of these effects3–10, we have investigated whether apomorphine or morphine stimulates prostaglandin biosynthesis. Here we describe experiments showing that both drugs stimulate, although possibly in a somewhat different way, the prostaglandin (PG) synthetase of bull seminal vesicles.

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Authors and Affiliations

  1. Miles Laboratories Limited, Stoke Poges, Slough, SL2 4LY, UK

    H. O. J. COLLIER, WENDY J. MCDONALD-GIBSON & S. A. SAEED

Authors
  1. H. O. J. COLLIER
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  2. WENDY J. MCDONALD-GIBSON
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  3. S. A. SAEED
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COLLIER, H., MCDONALD-GIBSON, W. & SAEED, S. Apomorphine and morphine stimulate prostaglandin biosynthesis. Nature 252, 56–58 (1974). https://doi.org/10.1038/252056a0

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  • DOI: https://doi.org/10.1038/252056a0

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