Skip to main content
SpringerLink
Log in

Physiological Disposition of Narcotic Agonists and Antagonists

  • Chapter
Narcotic Drugs

Abstract

The disposition and metabolism of narcotic drugs have been an extremely active area of research during the past few decades. Much effort has been extended in this area due to two factors: (1) a search for the mechanism of action of analgesic drugs and/or the mechanism of tolerance and physical dependence and (2) the need for basic data concerning the disposition and metabolism of a new drug prior to release for clinical experimentation and subsequent filing of a new drug application.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. E. L. Way and T. K. Adler, Pharmacol. Rev. 12, 383–445 (1960).

    PubMed  CAS  Google Scholar 

  2. E. L. Way and T. K. Adler, “The Biological Disposition of Morphine and its Surrogates,” World Health Organization, Geneva, pp. 1–114 (1962).

    Google Scholar 

  3. E. L. Way, in The Addictive States (A. Wikler, ed.), Vol. 46, pp. 13–31, Williams & Wilkins, Baltimore (1968).

    Google Scholar 

  4. E. Nelson, J. Pharm. Sci., 50, 181–192 (1961).

    Article  PubMed  CAS  Google Scholar 

  5. B. B. Brodie and C. A. M. Hogben, J. Pharm. Pharmacol. 9, 345–380 (1957).

    Article  PubMed  CAS  Google Scholar 

  6. J. G. Wagner, J. Pharm. Sci. 56, 489–494 (1967).

    Article  PubMed  CAS  Google Scholar 

  7. J. H. Fincher, J. Pharm. Sci. 57, 1825–1835 (1968).

    Article  PubMed  CAS  Google Scholar 

  8. A. Goldstein, L. Arnow, and S. M. Kaiman, “Principles of Drug Action,” Hoeber Medical Division, Harper & Row, New York (1968).

    Google Scholar 

  9. C. G. Farmilo, P. M. Oestreicher, and L. Levi, Bull. Narcotics 6, 7–19 (1954).

    CAS  Google Scholar 

  10. L. B. Mellett, unpublished observations.

    Google Scholar 

  11. S. J. Kety, in “Handbook of Physiology” (J. Field, H. W. Magoon, and L. E. Hall, eds.), Vol. III, “Neurophysiology,” Chapter 71, American Physiological Society, Washington, D.C. (1960).

    Google Scholar 

  12. B. B. Brodie, H. Kurr, and L. Shanker, J. Pharmacol. Exp. Ther. 130, 20–25 (1960).

    PubMed  CAS  Google Scholar 

  13. L. J. Shanker, Ann. Rev. Pharmacol. 1, 29–44 (1961).

    Article  Google Scholar 

  14. D. P. Rall and C. G. Zabrod, Ann. Rev. Pharmacol. 2, 109–128 (1962).

    Article  CAS  Google Scholar 

  15. L. J. Roth and L. F. Barlow, Science 134, 22–31 (1961).

    Article  PubMed  CAS  Google Scholar 

  16. W. Feldberg, “A Pharmacological Approach to the Brain, from its Inner and Outer Surface,” Williams & Wilkins, Baltimore (1963).

    Google Scholar 

  17. S. J. Mulé, Arch Int. Pharmacodyn. 173, 201–212 (1968).

    PubMed  Google Scholar 

  18. R. T. Williams, “Detoxication Mechanisms,” Wiley, New York (1959).

    Google Scholar 

  19. J. M. Fujimoto and E. L. Way, Fed. Proc. 13, 58 (1954).

    Google Scholar 

  20. R. A. Seibert, C. W. Williams, and R. A. Huggins, Science 120, 222 (1954).

    Article  PubMed  CAS  Google Scholar 

  21. L. A. Woods, J. Pharmacol. Exp. Ther. 112, 158–175 (1954).

    PubMed  CAS  Google Scholar 

  22. J. L. Strominger, H. M. Kalckar, J. Axelrod, and E. S. Maxwell, J. Amer. Chem. Soc. 76, 6411–6412 (1954).

    Article  CAS  Google Scholar 

  23. A. E. Takemori, J. Pharmacol. Exp. Ther. 130, 370–374 (1960).

    PubMed  CAS  Google Scholar 

  24. T. K. Adler, in “Current Trends in Heterocyclic Chemistry” (A. Albert, G. M. Bodger, and C. W. Shappee, eds.), Butterworths, London, pp. 151–157 (1958).

    Google Scholar 

  25. L. A. Woods and H. E. Muehlenbeck, J. Pharmacol. Exp. Ther. 120, 52–57 (1957).

    PubMed  CAS  Google Scholar 

  26. G. J. Mannering and L. S. Schanker, J. Pharmacol. Exp. Ther. 124, 296–304 (1958).

    PubMed  CAS  Google Scholar 

  27. C. C. Hug, Jr., and L. B. Mellett, J. Pharmacol. Exp. Ther. 149, 446–453 (1965).

    PubMed  CAS  Google Scholar 

  28. H. Fisher and J. P. Long, J. Pharmacol. Exp. Ther. 107, 241–246 (1953).

    PubMed  CAS  Google Scholar 

  29. N. P. Plotnikoff, E. L. Way, and H. W. Elliott, J. Pharmacol. Exp. Ther. 117, 414–419 (1956).

    PubMed  CAS  Google Scholar 

  30. S. J. Mulé and C. W. Gorodetzky, J. Pharmacol. Exp. Ther. 154, 632–645 (1966).

    PubMed  Google Scholar 

  31. S. J. Mulé, T. H. Clements, and C. W. Gorodetzky, J. Pharmacol. Exp. Ther. 160, 387–396 (1968).

    PubMed  Google Scholar 

  32. J. M. Fujimoto and V. B. Haarstad, J. Pharmacol. Exp. Ther. 165, 45–51 (1969).

    PubMed  CAS  Google Scholar 

  33. J. M. Fujimoto, W. W. Watrous, and V. B. Haarstad, Proc. Soc. Exp. Biol. Med. 130, 546–549 (1969).

    PubMed  CAS  Google Scholar 

  34. J. R. Gillette, in “Progress in Drug Research” (E. Tucker, ed.), Vol. 6, pp. 11–51, Birkhauser Verlag, Basel (1963).

    Google Scholar 

  35. A. H. Beckett, J. Pharm. Pharmacol. 8, 848–859 (1956).

    Article  PubMed  CAS  Google Scholar 

  36. J. Axelrod, Science 124, 263–264 (1956).

    Article  PubMed  CAS  Google Scholar 

  37. D. H. Clouet, “International Review of Neurobiology,” Vol. II, pp. 99–128, Academic Press, New York (1968).

    Google Scholar 

  38. T. K. Adler, Proc. Soc. Exp. Biol. Med. 73, 401–404 (1950).

    CAS  Google Scholar 

  39. T. K. Adler, J. Pharmacol. Exp. Ther. 103, 337 (1951).

    Google Scholar 

  40. T. K. Adler, J. Pharmacol. Exp. Ther. 106, 371 (1952).

    Google Scholar 

  41. G. J. Mannering, A. C. Dixon, E. M. Baker, and T. Asami, J. Pharmacol. Exp. Ther. 111, 142–146 (1954).

    PubMed  CAS  Google Scholar 

  42. T. K. Adler, J. Pharmacol. Exp. Ther. 140, 155–161 (1963).

    PubMed  CAS  Google Scholar 

  43. J. W. Miller and H. W. Elliott, J. Pharmacol. Exp. Ther. 113, 283–291 (1955).

    PubMed  CAS  Google Scholar 

  44. S. Y. Yeh and L. A. Woods, J. Pharmacol. Exp. Ther. 166, 86–95 (1969).

    PubMed  CAS  Google Scholar 

  45. P. Paerregaard, Acta Pharmacol. Toxicol. 14, 394–399 (1958).

    Article  CAS  Google Scholar 

  46. L. A. Woods, H. E. Muehlenbeck, and L. B. Mellett, J. Pharmacol. Exp. Ther. 117, 117–125 (1956).

    PubMed  CAS  Google Scholar 

  47. T. K. Adler, J. M. Fujimoto, E. L. Way, and E. M. Baker, J. Pharmacol. Exp. Ther. 114, 251 (1955).

    PubMed  CAS  Google Scholar 

  48. A. E. Takemori and G. J. Mannering, J. Pharmacol. Exp. Ther. 123, 171–179 (1958).

    PubMed  CAS  Google Scholar 

  49. E. L. Way, J. W. Kemp, J. M. Young, and D. R. Grassetti, J. Pharmacol. Exp. Ther. 129, 144–151 (1960).

    PubMed  CAS  Google Scholar 

  50. E. L. Way, J. M. Young, and J. W. Kemp, Bull. Narcotics 17, 25–33 (1965).

    CAS  Google Scholar 

  51. J. J. Burns, B. L. Berger, P. A. Lief, A. Wollack, E. M. Papper, and B. B. Brodie, J. Pharmacol. Exp. Ther. 114, 289–295 (1955).

    PubMed  CAS  Google Scholar 

  52. F. Bernheim and M. Bernheim, J. Pharmacol. Exp. Ther. 85, 74–77 (1945).

    PubMed  CAS  Google Scholar 

  53. E. L. Way, R. Swanson, and A. Gimble, J. Pharmacol. Exp. Ther. 91, 178–184 (1947).

    PubMed  CAS  Google Scholar 

  54. W. P. Baker and L. A. Woods, J. Pharmacol. Exp. Ther. 120, 371–374 (1957).

    PubMed  CAS  Google Scholar 

  55. C. C. Hug, L. B. Mellett, and E. J. Cafruny, J. Pharmacol. Exp. Ther. 150, 259–269 (1965).

    PubMed  CAS  Google Scholar 

  56. C. H. March and H. W. Elliott, Proc. Soc. Exp. Biol. Med. 86, 494–497 (1954).

    PubMed  CAS  Google Scholar 

  57. J. Cochin, J. Haggart, L. A. Woods, and M. H. Seevers, J. Pharmacol. Exp. Ther. 111, 74–83 (1954).

    PubMed  CAS  Google Scholar 

  58. L. B. Mellett and L. A. Woods, J. Pharmacol. Exp. Ther. 116, 77–83 (1956).

    PubMed  CAS  Google Scholar 

  59. L. A. Woods, J. Pharmacol. Exp. Ther. 120, 58–62 (1956).

    Google Scholar 

  60. S. J. Mulé and L. A. Woods, J. Pharmacol. Exp. Ther. 136, 232–241 (1962).

    PubMed  Google Scholar 

  61. S. J. Mulé, L. A. Woods, and L. B. Mellett, J. Pharmacol. Exp. Ther. 136, 242–249 (1962).

    PubMed  Google Scholar 

  62. S. J. Mulé, J. Pharmacol. Exp. Ther. 148, 393–398 (1965).

    PubMed  Google Scholar 

  63. R. Siminoff and P. R. Saunders, J. Pharmacol. Exp. Ther. 124, 252–254 (1958).

    PubMed  CAS  Google Scholar 

  64. T. K. Adler, H. W. Elliott, and R. George, J. Pharmacol. Exp. Ther. 120, 475–487 (1957).

    PubMed  CAS  Google Scholar 

  65. J. C. Szerb and D. H. McCurdy, J. Pharmacol. Exp. Ther. 118, 446–450 (1956).

    PubMed  CAS  Google Scholar 

  66. T. Johannesson, Acta Pharmacol. Toxicol. 19, 286–292 (1962).

    Article  CAS  Google Scholar 

  67. T. Johannesson and K. Milthers, Acta Pharmacol. Toxicol. 19, 241–246 (1962).

    Article  Google Scholar 

  68. T. Johannesson, Acta Pharmacol. Toxicol. 19, 23–35 (1962).

    Article  CAS  Google Scholar 

  69. K. Milthers, Nature 195, 607 (1962).

    Article  PubMed  CAS  Google Scholar 

  70. K. Milthers, Acta Pharmacol. Toxicol. 19, 235–240 (1962).

    Article  CAS  Google Scholar 

  71. T. Johannesson and J. Schou, Acta Pharmacol. Toxicol. 20, 165–173 (1963).

    Article  CAS  Google Scholar 

  72. T. Johannesson and K. Milthers, Acta Pharmacol. Toxicol 20, 80–89 (1963).

    Article  CAS  Google Scholar 

  73. T. Johannesson and L. A. Woods, Acta Pharmacol. Toxicol. 21, 381–396 (1964).

    Article  CAS  Google Scholar 

  74. S. J. Mulé, C. M. Redman, and J. W. Flesher, J. Pharmacol. Exp. Ther. 157, 459–471 (1967).

    PubMed  Google Scholar 

  75. H. I. Chernov and L. A. Woods, J. Pharmacol. Exp. Ther. 149, 146–155 (1965).

    PubMed  CAS  Google Scholar 

  76. C. C. Hug, doctoral dissertation, University of Michigan, Ann Arbor, pp. 1–205 (1963).

    Google Scholar 

  77. C. F. Blane and H. Dobbs, Brit. J. Pharmacol. Chemother. 30, 166–172 (1967).

    CAS  Google Scholar 

  78. J. H. Samer and L. A. Woods, J. Pharmacol. Exp. Ther. 148, 176–184 (1965).

    Google Scholar 

  79. S. Y. Yeh and L. A. Woods, J. Pharmacol. Exp. Ther. 166, 86–95 (1969).

    PubMed  CAS  Google Scholar 

  80. K. D. Wuepper, S. Y. Yeh and L. A. Woods, Proc. Soc. Exp. Biol Med. 124, 1146–1149 (1967).

    PubMed  CAS  Google Scholar 

  81. C. C. Hug and L. A. Woods, J. Pharmacol. Exp. Ther. 142, 248–256 (1963).

    PubMed  CAS  Google Scholar 

  82. K. D. Wuepper and L. A. Woods, Fed. Proc. 19, 272 (1960).

    Google Scholar 

  83. R. Ferrari, Pharmacologist 7, 148 (1965).

    Google Scholar 

  84. R. Ferrari and J. D. Connolly, Pharmacologist 8, 224 (1966).

    Google Scholar 

  85. J. Heng and L. A. Woods, Fed. Proc. 17, 376 (1968).

    Google Scholar 

  86. E. L. Way, A. I. Gimble, W. P. McKelway, H. Ross, Chen-Yo Sung, and H. Ellsworth, J. Pharmacol. Exp. Ther. 96, 477–484 (1949).

    PubMed  CAS  Google Scholar 

  87. E. L. Way, Chen-Yo Sung, and W. P. McKelway, J. Pharmacol. Exp. Ther. 97, 222–228 (1949).

    Google Scholar 

  88. J. C. Richards, G. E. Boxer, and C. C. Smith, J. Pharmacol. Exp. Ther. 98, 380–391 (1950).

    Google Scholar 

  89. L. A. Woods, J. Cochin, E. G. Fornfeld, and M. H. Seevers, J. Pharmacol. Exp. Ther. 111, 64–73 (1954).

    PubMed  CAS  Google Scholar 

  90. H. W. Elliott, F. N. H. Chang, I. A. Abdou, and H. H. Anderson, J. Pharmacol. Exp. Ther. 95, 494–501 (1949).

    PubMed  CAS  Google Scholar 

  91. N. B. Eddy, H. Halbach, O. J. Brenden, Bull. W. H. O. 14, 353–402 (1956).

    PubMed  CAS  Google Scholar 

  92. D. Van Praag and E. J. Simon, Proc. Soc. Exp. Biol. Med. 122, 6–11 (1966).

    PubMed  Google Scholar 

  93. A. H. Beckett, A. F. Casy, and N. J. Harper, J. Pharm. Pharmacol. 8, 874–883 (1956).

    Article  PubMed  CAS  Google Scholar 

  94. A. L. Misra, S. J. Mulé, and L. A. Woods, J. Pharmacol. Exp. Ther. 132, 317–322 (1961).

    PubMed  CAS  Google Scholar 

  95. A. L. Misra, H. I. Jacoby, and L. A. Woods, J. Pharmacol. Exp. Ther. 132, 311–316 (1961).

    PubMed  CAS  Google Scholar 

  96. N. P. Plotnikoff, H. W. Elliott, and E. L. Way, J. Pharmacol. Exp. Ther. 104, 377–386 (1952).

    PubMed  CAS  Google Scholar 

  97. L. A. Woods, L. B. Mellett, and K. J. Anderson, J. Pharmacol. Exp. Ther. 124, 1–8 (1958).

    PubMed  CAS  Google Scholar 

  98. V. P. Dole and M. E. Nyswander, J. Amer. Med. Ass. 193, 647–650 (1965).

    Article  Google Scholar 

  99. V. P. Dole and M. E. Nyswander, Brit. J. Addict. 63, 55–57 (1968).

    Article  CAS  Google Scholar 

  100. A. H. Beckett, J. F. Taylor, A. F. Casy, and M. M. A. Hassan, J. Pharm. Pharmacol. 20, 754–762 (1968).

    Article  PubMed  CAS  Google Scholar 

  101. W. R. Martin, Pharm. Rev. 19, 464–521 (1967).

    Google Scholar 

  102. S. Archer and L. S. Harris, in “Progress in Drug Research” (E. J. Jucker, ed.), pp. 261–320, Birkhauser Verlag, Basel (1965).

    Google Scholar 

  103. R. A. Ferrari, Toxicol. Appl. Pharm. 12, 404–416 (1968).

    Article  CAS  Google Scholar 

  104. A. S. Kates and J. Telford, J. Pharmacol. Exp. Ther. 143, 157–164 (1964).

    Google Scholar 

  105. J. Cochin, in “Enzymes in Mental Health” (G. J. Martin and B. Kisch, eds.), pp. 27–42, Lippincott, Philadelphia (1966).

    Google Scholar 

  106. M. H. Seevers and L. A. Woods, Amer. J. Med. 14, 546–557 (1953).

    Article  PubMed  CAS  Google Scholar 

  107. N. B. Eddy, H. Halbach, H. Isbell, and M. H. Seevers, Bull. W. H. O. 32, 721–733 (1965).

    PubMed  CAS  Google Scholar 

  108. L. B. Mellett and L. A. Woods, Prog. Drug Res. 5, 157–267 (1963).

    Google Scholar 

  109. M. H. Seevers and G. A. Deneau, Arch Int. Pharmacodyn. 140, 514–520 (1962).

    PubMed  CAS  Google Scholar 

  110. W. R. Martin, in “The Addictive States” (A. Wikler, ed.), Vol. 46, pp. 206–225, Williams & Wilkins, Baltimore (1968).

    Google Scholar 

  111. J. H. Jaffe and S. K. Sharpless, in “The Addictive States” (A. Wikler, ed.), Vol. 46, 226–246, Williams & Wilkins, Baltimore (1968).

    Google Scholar 

  112. J. Axelrod, in “The Addictive States” (A. Wikler, ed.), Vol. 46, 247–264, Williams & Wilkins, Baltimore, (1968).

    Google Scholar 

  113. A. Goldstein and D. B. Goldstein, in “The Addictive States” (A. Wikler, ed.), Vol. 46, 265–267, Williams & Wilkins, Baltimore (1968).

    Google Scholar 

  114. N. D. Eddy, in “Origin of Resistence to Toxic Agents” (M. G. Sevay, R. D. Reid, and O. E. Reynolds, eds.), pp. 223–243, Academic Press, New York (1955).

    Google Scholar 

  115. S. J. Mulé, in “Scientific Basis of Drug Dependence” (H. Steinberg, ed.), pp. 97–109, Churchill Ltd., London (1969).

    Google Scholar 

  116. L. A. Woods, Pharm. Rev. 84, 175–198 (1956).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. New York State Narcotic Addiction Control Commission, New York, New York, USA

    Salvatore J. Mulé

Authors
  1. Salvatore J. Mulé
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. New York State Research Institute for Neurochemistry and Drug Addiction, New York, New York, USA

    Doris H. Clouet

  2. Narcotic Addiction Control Commission, New York, New York, USA

    Doris H. Clouet

Rights and permissions

Reprints and permissions

Copyright information

© 1971 Plenum Press, New York

About this chapter

Cite this chapter

Mulé, S.J. (1971). Physiological Disposition of Narcotic Agonists and Antagonists. In: Clouet, D.H. (eds) Narcotic Drugs. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1869-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-1869-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-1871-2

  • Online ISBN: 978-1-4684-1869-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation