Abstract
The temperate bacteriophages P22 of Salmonella typhimurium and λ of Escherichia coli form viable hybrids in which the immunity, early control and DNA replication genes of P22 are substituted for the analogous λ genes. The specificity of the early control and DNA replication genes differs between P22 and λ; the immunity of the hybrid is identical with that of the lambdoid coliphage 21. Implications for the evolution of viruses are discussed.
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Botstein, D., Herskowitz, I. Properties of hybrids between Salmonella phage P22 and coliphage λ. Nature 251, 584–589 (1974). https://doi.org/10.1038/251584a0
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DOI: https://doi.org/10.1038/251584a0
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