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Transplantation of allogeneic lymphoid cells specifically depleted of graft versus host reactive cells

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Abstract

GRAFT versus host (GvH) disease has been a major problem in the transplantation of allogeneic haematopoietic or immunocompetent lymphoid cells. In man, attempts to reduce the GvH effect of transplanted allogeneic cells, including HL-A matching1,2, cell separation techniques3, anti-lymphocyte globulin4, and injection of small doses of bone marrow cells5, have aided successful bone marrow transplantation. Various techniques have been used in animal systems6–14 to reduce the GvH reaction by removing reactive cells from populations of lymphoid cells. So far, however, there has been no attempt to assess the potential value of such specifically depleted cells in transplantation.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, School of Medicine, University of California, Los Angeles, California, 90024

    BENJAMIN BONAVIDA & ELI KEDAR

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  1. BENJAMIN BONAVIDA
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  2. ELI KEDAR
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BONAVIDA, B., KEDAR, E. Transplantation of allogeneic lymphoid cells specifically depleted of graft versus host reactive cells. Nature 249, 658–659 (1974). https://doi.org/10.1038/249658a0

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  • DOI: https://doi.org/10.1038/249658a0

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