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No interaction between ultraviolet and X irradiation on chromosome aberrations in cells with trisomy 21

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Abstract

WE have previously shown1 that ultraviolet irradiation of normal human lymphocytes immediately before or after X irradiation gives an approximately two-fold increase of the frequency of dicentric chromosomes as compared with the yield induced by X rays alone. Ultraviolet light itself induces very few dicentrics. One interpretation of this synergistic reaction might be that lesions induced by X rays are transformed into chromosome breaks by the ultraviolet treatment.

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References

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Authors and Affiliations

  1. Research Institute of National Defense, Departments 4, S-104 01, Stockholm, 80

    M. HOLMBERG

  2. Department of Clinical Genetics, Karolinska Hospital, S-104 01, Stockholm, 60

    M. HOLMBERG

Authors
  1. M. HOLMBERG
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HOLMBERG, M. No interaction between ultraviolet and X irradiation on chromosome aberrations in cells with trisomy 21. Nature 249, 448–449 (1974). https://doi.org/10.1038/249448a0

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  • DOI: https://doi.org/10.1038/249448a0

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