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Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid

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Abstract

L-GLUTAMIC acid is probably an excitatory transmitter of major significance in the mammalian central nervous system1. The L-glutamic acid molecule is relatively flexible, and in an attempt to gain some insight into its possible shape(s) during activation of receptors associated with excitation of central neurones, a study was made of four conformationally restricted analogues: (±)-cis-1-aminocyclohexane-1,3-dicarboxylic acid (‘cyclo-glutamic’ acid), ibotenic acid, kainic acid and its dihydro derivative.

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Authors and Affiliations

  1. Department of Pharmacology, Australian National University, Canberra, Australia

    G. A. R. JOHNSTON, D. R. CURTIS, J. DAVIES & R. M. MCCULLOCH

Authors
  1. G. A. R. JOHNSTON
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  2. D. R. CURTIS
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  3. J. DAVIES
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  4. R. M. MCCULLOCH
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JOHNSTON, G., CURTIS, D., DAVIES, J. et al. Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid. Nature 248, 804–805 (1974). https://doi.org/10.1038/248804a0

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  • DOI: https://doi.org/10.1038/248804a0

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