Skip to main content
SpringerLink
Log in

Reduction in the Concentration of Nerve Growth Factor in Mice after Sialectomy and Castration

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Surgical removal of the submaxillary glands in adult mice causes a profound drop in the plasma and tissue concentrations of nerve growth factor, and a reduction in the activity of tyrosine hydroxylase within sympathetic ganglia. NGF may be the protein which fulfils the retrograde flow of information from the axon terminal to the cell body.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hendry, I. A., Biochem. J., 128, 1255 (1972).

    Article  Google Scholar 

  2. Levi-Montalcini, R., and Angeletti, P. U., Proceedings of the Fourth Int. Neurochemical Symp. (edit. by Kety and Elks), 362 (1961).

    Google Scholar 

  3. Varon, S., Nomura, J., and Shooter, E., Biochemistra, 7, 1296 (1968).

    Article  CAS  Google Scholar 

  4. Hendry, I. A., and Iversen, L. L., Brain Res., 29, 159 (1971).

    Article  CAS  Google Scholar 

  5. Black, I. B., Hendry, I. A., and Iversen, L. L., Nature New Biology, 231, 27 (1971).

    CAS  PubMed  Google Scholar 

  6. Black, I. B., Hendry, I. A., and Iversen, L. L., J. Neurochem., 19, 1367 (1972).

    Article  CAS  Google Scholar 

  7. Levi-Montalcini, R., Meyer, H., and Hamburger, V., Cancer Res., 14, 49 (1945).

    Google Scholar 

  8. Molinoff, P. B., Brimijoin, S., Weinshilbourn, R., and Axelrod, J., Proc. US Nat. Acad. Sci., 66, 453 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Mueller, R. A., Thoenen, H., and Axelrod, J., J. Pharmac. Exp. Ther., 169, 74 (1969).

    CAS  Google Scholar 

  10. Mueller, R. A., Thoenen, H., and Axelrod, J., Science, 163, 468 (1969).

    Article  ADS  CAS  Google Scholar 

  11. Mueller, R. A., Thoenen, H., and Axelrod, J., Mol. Pharmac., 5, 463 (1969).

    CAS  Google Scholar 

  12. Mueller, R. A., Theonen, H., and Axelrod, J., Eur. J. Pharmac., 10, 51 (1970).

    Article  CAS  Google Scholar 

  13. Hamburger, V., J. Exp. Zool., 68, 449 (1934).

    Article  Google Scholar 

  14. Prestige, M. C., J. Embryol. Exp. Morph., 13, 63 (1965).

    CAS  PubMed  Google Scholar 

  15. Prestige, M. C., J. Embryol. Exp. Morph., 17, 453 (1967).

    CAS  PubMed  Google Scholar 

  16. Prestige, M. C., J. Embryol. Exp. Morph., 18, 359 (1967).

    CAS  PubMed  Google Scholar 

  17. Cragg, B. G., Brain Res., 23, 1 (1970).

    Article  CAS  Google Scholar 

  18. La Vail, J. M., and La Vail, M. M., Science, 176, 1416 (1972).

    Article  ADS  CAS  Google Scholar 

  19. Levi-Montalcini, R., and Hamburger, V., J. Exp. Zool., 116, 321 (1951).

    Article  CAS  Google Scholar 

  20. Levi-Montalcini, R., and Hamburger, V., J. Exp. Zool., 123, 233 (1953).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Neurochemical Pharmacology Unit, Department of Pharmacology, University of Cambridge, Cambridge

    I. A. HENDRY & L. L. IVERSEN

Authors
  1. I. A. HENDRY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. L. IVERSEN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HENDRY, I., IVERSEN, L. Reduction in the Concentration of Nerve Growth Factor in Mice after Sialectomy and Castration. Nature 243, 500–504 (1973). https://doi.org/10.1038/243500a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/243500a0

  • Springer Nature Limited

This article is cited by

Search

Navigation