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Influence of Cell-free Ascites Fluid and Adenosine 3′5′-Cyclic Monophosphate upon the Cell Kinetics of Ehrlich's Ascites Carcinoma

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Abstract

CELL and tissue growth regulation occurs in response to specific stimuli. Bullough1,2 has shown that a number of tissues contain a saline-extractable, cell-specific substance, chalone, which can depress the mitotic activity of the corresponding cells in these tissues. He concluded that the presence of adrenaline and hydrocortisone was necessary in order to activate the chalone.

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Authors and Affiliations

  1. Department of Pharmacology, School of Pharmacy, Sunderland Polytechnic, Chester Road, Sunderland, SR1 3SD

    PAMELA R. COOPER & H. SMITH

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  1. PAMELA R. COOPER
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  2. H. SMITH
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COOPER, P., SMITH, H. Influence of Cell-free Ascites Fluid and Adenosine 3′5′-Cyclic Monophosphate upon the Cell Kinetics of Ehrlich's Ascites Carcinoma. Nature 241, 457–458 (1973). https://doi.org/10.1038/241457a0

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