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‘Tuftsin’: a Natural Phagocytosis Stimulating Peptide

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Abstract

WE have shown in this laboratory that a specific cell bound leucophilic γ-globulin fraction, leucokinin, is essential for maximal stimulation of the phagocytic activity of the blood neutrophilic leucocyte1,2. We now report that the whole stimulatory effect of leucokinin can be ascribed to a single peptide fragment liberated by a specific enzyme in the outer membrane of the neutrophile. We shall refer to this peptide as ‘tuftsin’ (after Tufts University) and to the enzyme as leucokininase. The peptide ‘tuftsin’ has been produced in vitro from a γ-globulin fraction, PC IV, by treatment with leucokininase. PC IV is prepared by chromatography on phosphocellulose columns3 and contains all the leucokinin activity of serum γ-globulin2.

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References

  1. Fidalgo, B. V., and Najjar, V. A., Proc. US Nat. Acad. Sci., 57, 957 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Fidalgo, B. V., and Najjar, V. A., Biochemistry, 6, 3386 (1967).

    Article  CAS  PubMed  Google Scholar 

  3. Thomaidis, T. S., Fidalgo, B. V., Harshman, S., and Najjar, V. A., Biochemistry, 6, 3369 (1967).

    Article  CAS  PubMed  Google Scholar 

  4. Rabinowitz, Y., Blood, 23, 811 (1964).

    CAS  PubMed  Google Scholar 

  5. Cohn, Z. A., and Hirsch, J. G., J. Exp. Med., 112, 983 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Najjar, V. A., Fidalgo, B. V., and Stitt, E., Biochemistry, 7, 2376 (1968).

    Article  CAS  PubMed  Google Scholar 

  7. Porter, R. R., Biochem. J., 73, 119 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Najjar, V. A., Lymphology, 3, 23 (1970).

    CAS  PubMed  Google Scholar 

  9. Fleishman, J. B., Pain, R. H., and Porter, R. R., Arch. Biochem. Biophys., Supplement 1, 176 (1962).

  10. Colowick, S. P., and Kaplan, N. O., Methods in Enzymology, 2, 1 (Academic Press, New York, 1955 and 1956).

    Google Scholar 

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Authors and Affiliations

  1. Division of Protein Chemistry, Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, 02111

    VICTOR A. NAJJAR & KENJI NISHIOKA

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  1. VICTOR A. NAJJAR
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  2. KENJI NISHIOKA
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NAJJAR, V., NISHIOKA, K. ‘Tuftsin’: a Natural Phagocytosis Stimulating Peptide. Nature 228, 672–673 (1970). https://doi.org/10.1038/228672a0

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  • DOI: https://doi.org/10.1038/228672a0

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