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Thermodynamics of the Reversible Oxygenation of Bis (Acetylacetone)-Ethylenediiminecobalt (II) in Pyridine

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Abstract

THE reversible reaction of certain cobalt chelates with molecular oxygen can be considered as a simple model of the reversible oxygen binding by haemoglobin and myoglobin1,2. It was recently pointed out3–6 that in suitable experimental conditions synthetic oxygen carriers show a reaction stoichiometry corresponding to one oxygen molecule per metal atom. In both cases the six-coordinated complex with oxygen can be formed by an equatorial tetradentate chelating agent and a donor ligand in the axial position trans to oxygen4. The reversibility of oxygenation seems to depend on a non-polar environment of the metal provided by the aprotic solvents in the simple complexes and by the hydrophobic pocket accommodating the haem in haemoglobin7.

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Authors and Affiliations

  1. Institute of Biochemistry and CNR Centre for Molecular Biology, University of Rome,

    G. AMICONI, M. BRUNORI & E. ANTONINI

  2. the Regina Elena Institute for Cancer Research, Rome

    E. ANTONINI

  3. Institute of Chemistry, University of Trieste, Trieste

    G. TAUZHER & G. COSTA

Authors
  1. G. AMICONI
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  2. M. BRUNORI
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  3. E. ANTONINI
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  4. G. TAUZHER
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  5. G. COSTA
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AMICONI, G., BRUNORI, M., ANTONINI, E. et al. Thermodynamics of the Reversible Oxygenation of Bis (Acetylacetone)-Ethylenediiminecobalt (II) in Pyridine. Nature 228, 549–551 (1970). https://doi.org/10.1038/228549a0

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  • DOI: https://doi.org/10.1038/228549a0

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