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Retrogenetic Expression: the Reappearance of Embryonal Antigens in Cancer Cells

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Abstract

VARIOUS reports of embryonal antigens in extracts of tumour tissues have appeared since 1932 (refs. 1–9). Such antigens, absent from homologous normal tissues, have been detected in colonic6, hepatic7 and lung cancers8. These findings stimulated a study of the possible universal appearance of embryonic antigens in cancer tissues.

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Authors and Affiliations

  1. Division of Cell Biochemistry, Sloan–Kettering Institute for Cancer Research, New York, NY, 10021

    ELLIOTT H. STONEHILL & AARON BENDICH

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  1. ELLIOTT H. STONEHILL
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  2. AARON BENDICH
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STONEHILL, E., BENDICH, A. Retrogenetic Expression: the Reappearance of Embryonal Antigens in Cancer Cells. Nature 228, 370–372 (1970). https://doi.org/10.1038/228370a0

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  • DOI: https://doi.org/10.1038/228370a0

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