Abstract
NOELL1 first showed that the c-wave of the vertebrate-electroretinogram (ERG) probably originates in the pigment epithelium because the c-wave disappeared in the rabbit after selective poisoning of the pigment epithelium by sodium iodate. Brown and Wiesel showed that the c-wave of the cat's local ERG attained maximum amplitude when the electrode was immediately adjacent to the pigment epithelium2. They also obtained more direct evidence during brief intracellular recordings from pigment epithelial cells, which revealed larger potentials of similar time course but opposite polarity to the c-wave2. We have now obtained stable intracellular recordings which permit the slow light-evoked responses of pigment epithelial cells to be described in detail and identified positively as the origin of the c-wave.
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STEINBERG, R., SCHMIDT, R. & BROWN, K. Intracellular Responses to Light from Cat Pigment Epithelium: Origin of the Electroretinogram c-Wave. Nature 227, 728–730 (1970). https://doi.org/10.1038/227728a0
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DOI: https://doi.org/10.1038/227728a0
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