Abstract
BOTH serological and cell-mediated immunological reactions of the primary host against his own tumour cells have been demonstrated in an increasing number of experimental tumours1; promising results have also been obtained with human tumour cells as antigens and patient's own serum as the source of antibody2–5, and some experiments suggest that cell mediated immune reactions may also be involved6–8. Stimulation of lymphocytes in mixed cultures in vitro is a possible method for the detection of antigenic differences between two types of cells9. We have observed an increase of thymidine incorporation in vitro into lymphocytes from the remission period, when cultivated in the presence of mitomycin C treated autologous leukaemic leucoblasts. The cells were from ten patients with acute leukaemia, nine acute lymphoblastic leukaemias and one acute myelo-blastic leukaemia with hyperleucocytosis (over 50,000 leucocytes per mm3).
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FRIDMAN, W., KOURILSKY, F. Stimulation of Lymphocytes by Autologous Leukaemic Cells in Acute Leukaemia. Nature 224, 277–279 (1969). https://doi.org/10.1038/224277a0
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DOI: https://doi.org/10.1038/224277a0
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