Abstract
INDOLES in nature display an extraordinary variety of biological actions1. We describe here a correlation between the resonance constants of a series of indoleakylamines and their potency in causing contraction of stomach.
Similar content being viewed by others
References
Heinzelman, R. V., and Szmuszkovicz, J., Prog. in Drug Research, 6, 75 (1963); see also Adv. in Pharmacology, 6A and 6B (1968).
Vane, J. R., Brit. J. Pharmacol., 14, 87 (1959).
Swain, C. G., and Lupton, jun., E. C., J. Amer. Chem. Soc., 90, 4328 (1968).
Hammett, L. P., Physical Organic Chemistry, 184 (McGraw-Hill, New York, 1940).
Green, J. P., and Malrieu, J. P., Proc. US Nat. Acad. Sci., 54, 659 (1965).
Winter, J. C., Gessner, P. K., and Godse, D. D., J. Med. Chem., 10, 856 (1967). Winter, J. C., and Gessner, P. K., J. Pharmacol. Exp. Therap., 162, 286 (1968).
Barlow, R. B., and Khan, I., Brit. J. Pharmacol., 14, 99 (1959).
Offerheimer, J., and Ariëns, J., Arch. Intern. Pharmacodyn., 164, 216 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KANG, S., GREEN, J. Resonance Constants and the Activities of Indolealkylamines on Stomach Muscle. Nature 222, 794–795 (1969). https://doi.org/10.1038/222794b0
Received:
Issue Date:
DOI: https://doi.org/10.1038/222794b0
- Springer Nature Limited