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Mechanism of Action of Aldosterone

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Abstract

ALDOSTERONE stimulates sodium transport across some epithelia including the distal kidney tubules and the isolated toad bladder preparation1. The effects of this mineralocorticoid on sodium transport are blocked by puromycin, which prevents ribosomal protein synthesis, and by actinomycin D, which prevents the DNA-dependent elaboration of messenger RNA2,3. The consequences of increased protein synthesis due to aldosterone have been found to be a stimulation of NADH-dependent oxidative phosphorylation4 and an increased supply of acetyl CoA5. What is not clear at present is the way in which the increased metabolism influences sodium transport.

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References

  1. Crabbé, J., J. Clin. Invest., 40, 2103 (1961).

    Article  Google Scholar 

  2. Edelman, I. S., Bogoroch, R., and Porter, G. A., Proc. US Nat. Acad. Sci., 50, 1169 (1963).

    Article  ADS  CAS  Google Scholar 

  3. Crabbé, J., and De Weer, P., Nature, 202, 298 (1964).

    Article  ADS  Google Scholar 

  4. Fanestil, D. D., Herman, T. S., Fimognari, G. M., and Edelman, I. S., in Regulatory Functions of Biological Membranes (ed., by Järneselt J.), p. 177 (Elsevier, 1968).

    Google Scholar 

  5. Sharp, G. W. G., Lichtenstein, N. S., and Leaf, A., Biochem. Biophys. Acta, 111, 329 (1965).

    Article  CAS  Google Scholar 

  6. Crabbé, J., Nature, 200, 787 (1963).

    Article  ADS  Google Scholar 

  7. Crabbé, J., and Ehrlich, E. N., Pflüges. Arch., 304, 284 (1968).

    Article  Google Scholar 

  8. Crabbé, J., and De Weer, P., Protides Biol. Fluids (edit. by Peeters, H.) 15, 213 (Elsevier, Amsterdam, 1968).

    Google Scholar 

  9. Sharp, G. W. G., and Leaf, A., Nature, 202, 1185 (1964).

    Article  ADS  CAS  Google Scholar 

  10. Fanestil, D. D., Porter, G. A., and Edelman, I. S., Biochim. Biophys. Acta, 135, 74 (1967).

    Article  CAS  Google Scholar 

  11. Cuthbert, A. W., and Painter, E., J. Physiol., 199, 593 (1968).

    Article  CAS  Google Scholar 

  12. Sharp, G. W. G., and Leaf, A., J. Biol. Chem., 240, 4816 (1965).

    CAS  Google Scholar 

  13. Cuthbert, A. W., and Painter, E., J. Pharm. Pharmacol., 20, 492 (1968).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Pharmacology, University of Cambridge,

    A. W. CUTHBERT & ELISABETH PAINTER

Authors
  1. A. W. CUTHBERT
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  2. ELISABETH PAINTER
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CUTHBERT, A., PAINTER, E. Mechanism of Action of Aldosterone. Nature 222, 280–281 (1969). https://doi.org/10.1038/222280a0

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  • DOI: https://doi.org/10.1038/222280a0

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