Skip to main content
Log in

Evidence for Genetic Expression of Integrated DNA in Lymphoma Cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

EVIDENCE suggesting genetic transformation in mammalian cells has been reported1–6. To test whether the integration of DNA7 is followed by its genetic expression, we have studied the transfer of resistance to 5-iodo-2′-deoxyuridine (IUdR) to lymphoma cells in culture.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Szybalska, E. H., and Szybalski, W., Proc. US Nat. Acad. Sci., 48, 2026 (1962).

    Article  ADS  CAS  Google Scholar 

  2. Bradley, T. R., Roosa, R. A., and Law, L. W., J. Cell. Comp. Physiol., 60, 127 (1962).

    Article  CAS  Google Scholar 

  3. Kraus, L. M., Nature, 192, 1055 (1961).

    Article  ADS  CAS  Google Scholar 

  4. Glick, J. L., and Salim, A. P., J. Cell. Biol., 33, 209 (1967).

    Article  CAS  Google Scholar 

  5. Podgejetskaja, D. J., Bresler, V. M., Surikov, I. M., Ignatova, T. N., and Olenov, J. N., Biochim. Biophys. Acta, 80, 110 (1964).

    Google Scholar 

  6. Majumadar, A., and Bose, S. K., Brit. J. Cancer, 22, 603 (1968).

    Article  Google Scholar 

  7. Ayad, S. R., and Fox, M., Nature, 220, 35 (1968).

    Article  ADS  CAS  Google Scholar 

  8. Glick, J. L., Cancer Res., 27, 2338 (1967).

    CAS  PubMed  Google Scholar 

  9. Ozer, H. L., J. Cell. Physiol., 68, 61 (1966).

    Article  CAS  Google Scholar 

  10. Mathias, A. P., and Fischer, G. A., Biochem. Pharmacol., 11, 69 (1962).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

FOX, M., FOX, B. & AYAD, S. Evidence for Genetic Expression of Integrated DNA in Lymphoma Cells. Nature 222, 1086–1087 (1969). https://doi.org/10.1038/2221086a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2221086a0

  • Springer Nature Limited

This article is cited by

Navigation