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Antiviral Effect of Daunomycin

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Abstract

Daunomycin, an antibiotic of the anthracycline group, acts chiefly on DNA and DNA-dependent RNA synthesis. Although too toxic for routine systemic administration, local application of daunomycin for the treatment of herpetic or vaccinial keratitis might be possible, particularly if the infecting virus has become resistant to 5-iodo-2-deoxyuridine.

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References

  1. Grein, A., Spalla, C., Di Marco, A., and Canevazzi, G., Giorn. Microbiol., 11, 109 (1963).

    Google Scholar 

  2. Sanfilippo, A., and Mazzoleni, R., Giorn. Microbiol., 12, 83 (1964).

    Google Scholar 

  3. Tan, C., Tasaka, H., Yu, K-P., Murphy, M. L., and Karnofsky, D. A., Cancer, 20, 333 (1967).

    Article  CAS  Google Scholar 

  4. Rusconi, A., and Calendi, E., Biochim. Biophys. Acta, 119, 413 (1966).

    Article  CAS  Google Scholar 

  5. Di Marco, A., Silvestrini, R., Di Marco, S., and Dasdia, T., J. Cell Biol., 27, 545 (1965).

    Article  CAS  Google Scholar 

  6. Silvestrini, R., Di Marco, A., Di Marco, S., and Dasdia, T., Tumori, 49, 399 (1963).

    Article  CAS  Google Scholar 

  7. Calendi, E., Di Marco, A., Reggiani, M., Scarpinato, B., and Valentini, L., Biochim. Biophys. Acta, 103, 25 (1965).

    Article  CAS  Google Scholar 

  8. Hartmann, G., Goller, H., Koschell, K., Kersten, W., and Kersten, H., Biochem. Z., 341, 126 (1964).

    PubMed  CAS  Google Scholar 

  9. Ward, D. C., Reich, E., and Goldberg, I. H., Science, 149, 1259 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Di Marco, A., Gaetani, M., Orezzi, P., Scarpinato, B. M., Silvestrini, R., Soldati, M., Dasdia, T., and Valentini, L., Nature, 201, 706 (1964).

    Article  ADS  CAS  Google Scholar 

  11. Kersten, W., and Kersten, H., Biochem. Z., 341, 174 (1965).

    PubMed  CAS  Google Scholar 

  12. Di Marco, A., Pathologie et Biologie, 15, 897 (1967).

    PubMed  CAS  Google Scholar 

  13. Costa, G., and Astaldi, G., Tumori, 50, 477 (1964).

    Article  CAS  Google Scholar 

  14. Di Marco, A., Soldati, M., Fioretti, A., and Dasdia, T., Tumori, 49, 235 (1963).

    Article  CAS  Google Scholar 

  15. Di Marco, A., Soldati, M., Fioretti, A., and Dasdia, T., Cancer Chemother. Rep., 38, 39 (1964).

    CAS  Google Scholar 

  16. Magliulo, E., Stassano, G., and Fiori, G. P., Haematologica, 49, 1091 (1964).

    CAS  Google Scholar 

  17. Dorigotti, L., Tumori, 50, 117 (1964).

    Article  CAS  Google Scholar 

  18. Simard, R., Cancer Res., 26, 2316 (1966).

    PubMed  CAS  Google Scholar 

  19. Finter, N. B., Virology, 24, 589 (1964).

    Article  CAS  Google Scholar 

  20. Ginzburg, Y., and Traub, A., Virology, 9, 671 (1959).

    Article  CAS  Google Scholar 

  21. Barry, I. D., Ives, D. R., and Cruickshank, J. G., Nature, 194, 1139 (1962).

    Article  ADS  CAS  Google Scholar 

  22. Reich, E., Franklin, R. M., Shatkin, A. J., and Tatum, E. L., Proc. Nat. Acad. Sci. Wash., 48, 1238 (1962).

    Article  ADS  CAS  Google Scholar 

  23. Reich, E., and Goldberg, I. H., in Progress in Nucleic Acid Research and Molecular Biology (edit. by Davidson, J. N., and Cohn, W. E.), 3, 184 (Academic Press, New York, 1964).

    Google Scholar 

  24. Rees, K. R., in The Interaction of Drugs and Subcellular Components on Animal Cells (edit. by Campbell, P. N.) (Churchill Ltd, London, 1968).

    Google Scholar 

  25. Read, L. J., and Muench, H., Amer. J. Hyg., 27, 493 (1938).

    Google Scholar 

  26. Bauer, D. J., and Apostolov, K., Science, 154, 796 (1966).

    Article  ADS  CAS  Google Scholar 

  27. Sabin, A. B., in Cellular Biology, Nucleic Acids and Viruses, 5, 113 (New York Academy of Sciences, 1957).

    Google Scholar 

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Authors and Affiliations

  1. Department of Bacteriology,

    A. COHEN

  2. Department of Chemical Pathology, University College Hospital Medical School, London

    E. H. HARLEY & K. R. REES

Authors
  1. A. COHEN
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  2. E. H. HARLEY
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  3. K. R. REES
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COHEN, A., HARLEY, E. & REES, K. Antiviral Effect of Daunomycin. Nature 222, 36–38 (1969). https://doi.org/10.1038/222036a0

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  • DOI: https://doi.org/10.1038/222036a0

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