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Specific Antiviral Activity of Pyrimidinedispirotripiperazinium Alone and in Combination with Acyclovir on a Herpes-Simplex-Virus Infection Model

  • MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
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Pharmaceutical Chemistry Journal Aims and scope

Efficacious antiviral analogs of viral nucleoside DNA-polymerase inhibitors are used to treat infections caused by herpes simplex virus (HSV) although their widespread use in clinical practice has caused drug-resistant HSV strains to develop. The drug substance pyrimidine-dispirotripiperazinium or 3,3-(2-methyl-5-nitropyrimidin-4,6-diyl)-bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hexadecane tetrachloride dihydrochloride (PDSTP) was previously synthesized by us and possessed high antiherpetic activity in vitro. The antiherpetic efficacy of the new drug substance was evaluated in vivo using a herpetic encephalitis mouse model and various treatment regimes (i.p. and peroral administration, monotherapy, combination therapy with acyclovir).

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Authors and Affiliations

  1. A. N. Bach Institute of Biochemistry, Federal Research Centre “Fundamentals of Biotechnology”, Russian Academy of Sciences, 33-2b, Leninskii Prosp., Moscow, 119071, Russia

    E. A. Novoselova, O. B. Ryabova & V. A. Makarov

  2. I. I. Mechnikov Research Institute of Vaccines and Sera, 5 Malyi, Kazennyi Pereul., Moscow, 105064, Russia

    I. A. Leneva

Authors
  1. E. A. Novoselova
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  2. O. B. Ryabova
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  3. I. A. Leneva
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  4. V. A. Makarov
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Corresponding author

Correspondence to E. A. Novoselova.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 9, pp. 3 – 8, September, 2019.

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Novoselova, E.A., Ryabova, O.B., Leneva, I.A. et al. Specific Antiviral Activity of Pyrimidinedispirotripiperazinium Alone and in Combination with Acyclovir on a Herpes-Simplex-Virus Infection Model. Pharm Chem J 53, 781–785 (2019). https://doi.org/10.1007/s11094-019-02079-9

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  • DOI: https://doi.org/10.1007/s11094-019-02079-9

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