Skip to main content
SpringerLink
Log in

Density Gradient Centrifugation of Red Blood cells carrying the Mammary Tumour Virus

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

SINCE the demonstration1 of mammary tumour virus (MTV) activity in the blood of mice of a high mammary cancer strain (C3H/Jax), blood-borne MTV activity has been described in other strains of mice carrying MTV2–5. It has been established that the MTV activity in blood is limited primarily to the red blood cell (RBC) fraction6. Thus we thought it interesting to determine whether all cells of the circulating RBC population carry RBC-borne MTV (R-MTV). It is not possible to determine the activity associated with the individual RBC because a large number of RBC are required for biological detection of R-MTV (our unpublished results). Some insight into this question could be gained, however, from the use of different populations of RBC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Woolley, G. W., Law, L. W., and Little, C. C., Cancer Res., 1, 955 (1941).

    CAS  Google Scholar 

  2. Bittner, J. J., Proc. Soc. Exp. Biol. and Med., 59, 43 (1945).

    Article  Google Scholar 

  3. Mühlbock, O., Acta Physiol. Pharmacol. Neerl., 1, 645 (1950).

    PubMed  Google Scholar 

  4. Hummel, K. P., and Little, C. C., J. Nat. Cancer Inst., 30, 593 (1963).

    CAS  PubMed  Google Scholar 

  5. Nandi, S., Proc. US Nat. Acad. Sci., 58, 485 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Nandi, S., Knox, D., DeOme, K. B., Handin, M., Finster, V. V., and Pickett, P. B., J. Nat. Cancer Inst., 36, 809 (1966).

    Article  CAS  Google Scholar 

  7. Lief, R. C., and Vinograd, J., Proc. US Nat. Acad. Sci., 51, 520 (1964).

    Article  ADS  Google Scholar 

  8. Bishop, C., and Prentice, T. C., J. Cell. Physiol., 67, 197 (1966).

    Article  CAS  Google Scholar 

  9. Nandi, S., J. Nat. Cancer Inst., 31, 75 (1963).

    CAS  PubMed  Google Scholar 

  10. Nandi, S., in Carcinogenesis: A Broad Critique, Proc. of the Twentieth Annual Symp. on Fundamental Cancer Bes., M. D. Anderson Hospital and Tumor Inst., Houston, 295 (The Williams and Wilkins Press, 1967).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Zoology and its Cancer Research, Genetics Laboratory, University of California, Berkeley

    Ross I. RITTER & S. NANDI

Authors
  1. Ross I. RITTER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. NANDI
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RITTER, R., NANDI, S. Density Gradient Centrifugation of Red Blood cells carrying the Mammary Tumour Virus. Nature 220, 403–404 (1968). https://doi.org/10.1038/220403a0

Download citation

  • Received:

  • Revised:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/220403a0

  • Springer Nature Limited

This article is cited by

Search

Navigation