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Repair of Alkylated DNA in Mammalian Cells

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Abstract

THE cytotoxic action of the difunctional alkylating agent mustard gas, di-(2-chloroethyl) sulphide, on mammalian cells has been clearly associated with its ability to interact with DNA. At low concentrations of the agent, the only detectable biochemical effect of this reaction is the inhibition of DNA synthesis1,2.

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References

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Author notes

  1. T. P. BRENT

    Present address: McGill University Cancer Research Unit, 3655 Drummond Street, Montreal, 2, Canada

Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, London, SW3

    J. J. ROBERTS, A. R. CRATHORN & T. P. BRENT

Authors
  1. J. J. ROBERTS
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  2. A. R. CRATHORN
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  3. T. P. BRENT
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ROBERTS, J., CRATHORN, A. & BRENT, T. Repair of Alkylated DNA in Mammalian Cells. Nature 218, 970–972 (1968). https://doi.org/10.1038/218970a0

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  • DOI: https://doi.org/10.1038/218970a0

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