Skip to main content
SpringerLink
Log in

Effect of Adenosine Diphosphate on Adhesiveness of Platelets in vitro and in vivo

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

ADENOSINE diphosphate (ADP) is known to cause reversible aggregation of human and animal platelets in vitro1–4. Hellem et al.5 used a column of glass beads6 to determine an increase, within certain limits, in the adhesiveness of platelets in response to ADP. Born and Cross7 and Chin8 have also shown that intravascular injection of ADP produces a rapid and transient decrease in the number of circulating platelets, which is probably caused by the adhesion of platelets to the endothelium and the aggregation of platelets leading to intravascular trapping7. Silver and Stehbens9 have used ear chambers to demonstrate the intravascular aggregation of platelets in rabbits caused by intravenous infusion of ADP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gaader, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).

    Article  ADS  Google Scholar 

  2. Born, G. V. R., Nature, 194, 927 (1962).

    Article  ADS  CAS  Google Scholar 

  3. Mitchell, J. R. A., and Sharp, A. A., Brit. J. Haematol., 10, 78 (1964).

    Article  CAS  Google Scholar 

  4. Regoli, D., and Clark, V., Nature, 200, 546 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Hellem, A. J., Ödegaard, A. E., and Skålhegg, B. A., Thromb. Diath. Hemorrh., 10, 61 (1963).

    CAS  Google Scholar 

  6. Hellem, A. J., Scand. J. Clin. Lab. Invest., 12, suppl. 51 (1960).

  7. Born, G. V. R., and Cross, M. J., Nature, 197, 974 (1963).

    Article  ADS  CAS  Google Scholar 

  8. Chin, J., Nature, 201, 1039 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Silver, M. D., and Stehbens, W. E., Nature, 205, 91 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Tanaka, R., Acta Haematol. Jap., 20, 270 (1957).

    Google Scholar 

  11. Kono, Y., Isobe, J., and Yamanaka, M., Acta Haematol. Jap., 29, 130 (1966).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Laboratory, Tokushima University Hospital, School of Medicine, Tokushima University, Tokushima, Japan

    MANABU YAMANAKA, JUNICHI ISOBE & YASUTA KONO

Authors
  1. MANABU YAMANAKA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JUNICHI ISOBE
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. YASUTA KONO
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

YAMANAKA, M., ISOBE, J. & KONO, Y. Effect of Adenosine Diphosphate on Adhesiveness of Platelets in vitro and in vivo. Nature 216, 175–176 (1967). https://doi.org/10.1038/216175a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216175a0

  • Springer Nature Limited

Search

Navigation