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Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline-N-oxide in Isolated Nuclei

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Abstract

4-NITROQUINOLINE-N-OXIDE (4-NQO) is a potent carcinogen1 and mutagen2, which has been shown to induce tumours in mammals3, cause nuclear abnormalities in Tetrahymena4 and induce alterations in tissue culture cell nuclei5.

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References

  1. Nakahara, W., Fukuoka, F., and Sugimura, T., Gann, 48, 129 (1957).

    PubMed  CAS  Google Scholar 

  2. Mashima, S., and Ideda, Y., App. Microbiol., 6, 45 (1958).

    Article  CAS  Google Scholar 

  3. Suzuki, T., Gann, 57, 169 (1966).

    PubMed  CAS  Google Scholar 

  4. Mita, R., Tokuzen, R., Fukuoka, F., and Nakahara, W., Gann, 57, 273 (1966).

    PubMed  CAS  Google Scholar 

  5. Reynold, R. C., Montgomery, P. O'B., and Karney, D. H., Cancer Res., 23, 535 (1963).

    Google Scholar 

  6. Levintow, L., and Darnell, J. E., J. Biol. Chem., 235, 70 (1960).

    PubMed  CAS  Google Scholar 

  7. Pegg, A. E., and Korner, A., Nature, 205, 904 (1966).

    Article  ADS  Google Scholar 

  8. Gelboin, H. V., Worthan, J. S., Wilson, R. G., Freidman, M., and Wogan, G. H., Science, 154, 1205 (1966).

    Article  ADS  CAS  Google Scholar 

  9. Goldbert, I. H., Biochim. Biophys. Acta, 51, 201 (1961).

    Article  Google Scholar 

  10. Burton, K., Biochem. J., 62, 315 (1956).

    PubMed  PubMed Central  CAS  Google Scholar 

  11. Nagata, C., Kodama, M., Tagashira, Y., and Imamura, A., Biopolymers, 4, 409 (1966).

    Article  CAS  Google Scholar 

  12. Hamilton, L. D., Fuller, W., and Reich, E., Nature, 198, 535 (1963).

    Article  Google Scholar 

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Authors and Affiliations

  1. University of Texas, Southwestern Medical School, Department of Pathology, Laboratories for Cell Research, Woodlawn Hospital, Dallas, Texas

    J. S. PAUL, R. C. REYNOLDS & P. O'B. MONTGOMERY jun.

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  1. J. S. PAUL
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  2. R. C. REYNOLDS
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  3. P. O'B. MONTGOMERY jun.
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PAUL, J., REYNOLDS, R. & MONTGOMERY, P. Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline-N-oxide in Isolated Nuclei. Nature 215, 749–750 (1967). https://doi.org/10.1038/215749a0

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