Skip to main content
SpringerLink
Log in

Influence of Denervation on Localization of Neurotoxins from Clapid Venoms in Rat Diaphragm

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

α-BUNGAROTOXIN1,2 isolated from the venom of Bungarus multicinctus, as well as cobra neurotoxin3,4 from the venom of Naja naja atra, has been found to block neuromuscular transmission by an antidepolarizing action similar to that of d-tubocurarine. These conclusions have been further supported by the autoradiographic findings that α-bungarotoxin labelled with iodine-131 (ref. 5), as well as cobra neurotoxin6, accumulates on the motor end-plate zone of the mouse diaphragm in the same way as d-tubocurarine7

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Chang, C. C., and Lee, C. Y., Arch. Intern. Pharmacodyn. Ther., 144, 241 (1963).

    CAS  Google Scholar 

  2. Lee, C. Y., and Chang, C. C., Intern. Symp. Animal Venoms, São Paulo, Brazil (1966).

  3. Su, C., Chang, C. C., and Lee, C. Y., Animal Toxins, 259 (Pergamon Press, Oxford and New York, 1966).

  4. Chang, C. C., and Lee, C. Y., Brit. J. Pharmacol. Chemother., 28, 172 (1966).

    Article  CAS  Google Scholar 

  5. Lee, C. Y., and Tseng, L. F., Toxicon, 3, 281 (1966).

    Article  CAS  Google Scholar 

  6. Lee, C. Y., Tseng, L. F., and Chiu, T. H., Seventh Intern. Cong. Biochem., Tokyo (1967).

  7. Waser, P. G., and Lüthi, U., Arch. Intern. Pharmacodyn. Ther., 112, 272 (1957).

    CAS  Google Scholar 

  8. Waser, P. G., J. Pharm. Pharmacol., 12, 577 (1966).

    Article  Google Scholar 

  9. Axelsson, J., and Thesleff, S., J. Physiol., 147, 178 (1959).

    Article  CAS  Google Scholar 

  10. Miledi, R., J. Physiol., 151, 1 (1960).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

    C. Y. LEE, L. F. TSENG & T. H. CHIU

Authors
  1. C. Y. LEE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. F. TSENG
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. H. CHIU
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LEE, C., TSENG, L. & CHIU, T. Influence of Denervation on Localization of Neurotoxins from Clapid Venoms in Rat Diaphragm. Nature 215, 1177–1178 (1967). https://doi.org/10.1038/2151177a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2151177a0

  • Springer Nature Limited

This article is cited by

Search

Navigation