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Reversibility of a Penicillamine Induced Defect in Collagen Aggregation

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Abstract

WE have recently reported that the administration of penicillamine (β,β-dimethylcysteine) results in a marked accumulation of soluble collagen in the skin of rats1. Ultra-centrifugal analysis of this thermally denatured material indicated that it consists almost exclusively of strands of α-collagen2. The pattern obtained appeared to be identical to that observed after the administration of lathyrogenic compounds such as β-aminopropionitrile3. In addition to the changes in solubility, animals treated with penicillamine also manifested a decrease in the tensile strength in the intact skin and in healing wounds1.

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References

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Authors and Affiliations

  1. Department of Biochemistry and Nutrition, School of Dentistry, University of Southern California, Los Angeles

    M. E. NIMNI, NANCY GERTH & L. A. BAVETTA

Authors
  1. M. E. NIMNI
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  2. NANCY GERTH
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  3. L. A. BAVETTA
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NIMNI, M., GERTH, N. & BAVETTA, L. Reversibility of a Penicillamine Induced Defect in Collagen Aggregation. Nature 213, 921–922 (1967). https://doi.org/10.1038/213921a0

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