Abstract
A SYSTEMIC research programme for the detection of eventual antigrowth factors in plant extracts revealed a potent antimitotic substance which was isolated from several varieties of Narcissus bulbs. The substance was called “narciclasine”. Antitumour activity was observed by Fitzgerald et al.1, who used crude preparations of Narcissus bulbs. They found that pure alkaloids from the same source appeared to be inactive.
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References
Fitzgerald, D. B., Hartwell, J. L., and Leiter, J., J. Nat. Cancer Inst., 20, 763 (1958).
Ceriotti, G., Giorn. Botan., 73, 139 (1966).
Piozzi, F., Fuganti, C., Mandelli, R., and Ceriotti, G., Tetrahedron Lett., (in the press).
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CERIOTTI, G. Narciclasine: an Antimitotic Substance from Narcissus Bulbs. Nature 213, 595–596 (1967). https://doi.org/10.1038/213595a0
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DOI: https://doi.org/10.1038/213595a0
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