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Rate-determining Step in the Action of L-Amino-acid Oxidase

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Abstract

ALTHOUGH detailed information concerning the substrate specificity1,2, co-factor requirement and physico-chemical properties2 of L-amino-acid oxidase is available, our knowledge of the mechanisms of the reactions catalysed by this enzyme leaves much to be desired. Radda3 has recently proposed a mechanism for the oxidation of phenylglycines by L-amino-acid oxidase which involves the elimination of the α-hydrogen as a hydride ion (or radical) followed by hydrolysis of the imine and dissociation of the enzyme-product complex.

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Authors and Affiliations

  1. Departments of Biochemical Pharmacology and Theoretical Biology, State University of New York at Buffalo, Buffalo, New York

    D. J. TRIGGLE & J. F. MORAN

Authors
  1. D. J. TRIGGLE
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  2. J. F. MORAN
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TRIGGLE, D., MORAN, J. Rate-determining Step in the Action of L-Amino-acid Oxidase. Nature 211, 307–308 (1966). https://doi.org/10.1038/211307a0

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