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Kinetic and mechanism of reactions of L-α-Glutamic acid and L-Glutamine with pyridoxal

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Abstract

The kinetics and mechanisms of condensation of pyridoxal with L-α-glutamic acid and L-glutamine were studied by UV spectroscopy and polarimetry. L-α-Glutamic acid reacts with pyridoxal to form a Schiff base whose subsequent hydrolysis gives rise to pyridoxamine and α-ketoglutaric acid. The reaction of Lglutamine with pyridoxal involves the Γ-NH2 group and affords a Schiff base whose subsequent hydrolysis gives rise to pyridoxamine and L-α-glutamic acid.

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Authors and Affiliations

  1. Institute of Chemistry and Chemical Technology, National Academy of Sciences of Kirgiz Republic, pr. Chui 267, Bishkek, 720071, Kirgizia

    F. V. Pishchugin & I. T. Tuleberdiev

Authors
  1. F. V. Pishchugin
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  2. I. T. Tuleberdiev
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Correspondence to F. V. Pishchugin.

Additional information

Original Russian Text © F.V. Pishchugin, I.T. Tuleberdiev, 2014, published in Zhurnal Obshchei Khimii, 2014, Vol. 84, No. 7, pp. 1167–1171.

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Pishchugin, F.V., Tuleberdiev, I.T. Kinetic and mechanism of reactions of L-α-Glutamic acid and L-Glutamine with pyridoxal. Russ J Gen Chem 84, 1362–1366 (2014). https://doi.org/10.1134/S1070363214070196

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  • DOI: https://doi.org/10.1134/S1070363214070196

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