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Effect of Total Dose, Dose Rate and Time of Irradiation on Synthesis of Deoxyribonucleic Acid

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Abstract

IT has been postulated that the process of DNA synthesis is radio-resistant. During the period of DNA synthesis of the cell cycle in regenerating rat liver, a large dose of radiation is required to produce any measurable effect1–3. This preliminary note reports three observations made from an in vivo investigation of the effect of X-irradiation on DNA synthesis in 21 h regenerating rat liver: (a) A small dose of radiation (94 rads) produces a significant depression in DNA synthesis; (b) for a specific total dose, the slower the dose rates of irradiation, the greater is the depression in DNA synthesis within certain limits; and (c) the time period of irradiation is a major factor in producing this change, while the effect of total dose is secondary within the range of the experiments.

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Authors and Affiliations

  1. Radiobiology and Biophysics Laboratory, Department of Radiology, University of Virginia School of Medicine, Charlottesville

    L. O. CHANG, S. S. WILLIAMS & W. B. LOONEY

Authors
  1. L. O. CHANG
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  2. S. S. WILLIAMS
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  3. W. B. LOONEY
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CHANG, L., WILLIAMS, S. & LOONEY, W. Effect of Total Dose, Dose Rate and Time of Irradiation on Synthesis of Deoxyribonucleic Acid. Nature 211, 300–302 (1966). https://doi.org/10.1038/211300b0

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