Abstract
THE spontaneous mammary tumour of the C3H mouse has been shown to be resistant to the inhibitory action of testosterone in vivo when the tumour was well established1. Glenn et al.2, however, demonstrated that the rat mammary fibro-adenoma was inhibited by testosterone injected subcutaneously, and that this tumour may become resistant to the hormone. They suggested that the latter tumour was able to resist inhibition because it was able to metabolize testosterone, but no evidence has been submitted to support this claim.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Muhlbock, O., in Endocrine Aspects of Breast Cancer, 291, edit. by Currie, A. R. (Livingstone Press, Edinburgh, 1958).
Glenn, E. M., Richardson, S. L., Bowman, B. J., and Lyster, S. C., in Biological Activities of Steroids in Relation to Cancer, 257, edit. by Pincus, G., and Vollmer, E. P. (Academic Press, New York, 1960).
Umbreit, W. W., Burris, R. H., and Stauffer, J. F., in Manometric Techniques, 149 (Burgess Publishing Co., Minnesota, 1957).
Manchester, K. L., and Krahl, M. E., J. Biol. Chem., 234, 2939 (1959).
Tyner, E. P., Heidelberger, C., and LePage, G. A., Cancer Res., 13, 186 (1953).
Samuels, L. T., McCaulay, C., and Sellers, D. M., J. Biol. Chem., 168, 477 (1947).
Savard, K., J. Biol. Chem., 202, 457 (1953).
Wotiz, H. H., Lemon, H. M., and Voulgaropoulos, A., J. Biol. Chem., 209, 437 (1954).
Heuson, J. C., and Legros, N., Cancer, 16, 404 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PARSONS, I. Inhibitory Action of Testosterone on Mouse Mammary Tumours in vitro. Nature 206, 717–718 (1965). https://doi.org/10.1038/206717a0
Published:
Issue Date:
DOI: https://doi.org/10.1038/206717a0
- Springer Nature Limited