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Preparation of Antiserum to an Antigen of Low Molecular Weight

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Abstract

THE molecular weight of a protein has been considered of prime importance in relation to its antigenicity. Thus a protein with a molecular weight of less than 10,000 has not been demonstrated to have stimulated the formation of antibody. Experiments using polymerized amino-acids illustrate this clearly1,2.

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References

  1. Maurer, P. H., Prog. Allerg., 8, 1 (1964).

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  2. Givol, D., Fuchs, S., and Sela, M., Biochim. Biophys. Acta, 63, 222 (1962).

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  3. Berglund, G., and Blombäck, B. (to be published).

  4. Blombäck, B., Blombäck, M., Edman, P., and Hessel, B., Nature, 193, 883 (1962).

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  5. Blombäck, B., Blomb¨ck, M., and Edman, P., Acta Chem. Scand., 17, 1184 (1963).

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BERGLUND, G. Preparation of Antiserum to an Antigen of Low Molecular Weight. Nature 206, 523–524 (1965). https://doi.org/10.1038/206523a0

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