Skip to main content
SpringerLink
Log in

Enzymatic Synthesis of Cyclo propane Fatty Aldehydes

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

FATTY aldehydes containing a cyclopropane ring have been isolated after acid methanolysis of the phospholipids obtained from Clostridium butyricum. 36 per cent by weight of the fatty aldehydes contained a cyclopropane ring1,2. Zalkin et al.3 and Chung and Law4 have shown that cyclopropane fatty acids are formed by the addition of a methyl group from S-adenosylmethionine to an unsaturated fatty acid moiety of phosphatidylethanolamine. An enzyme which catalyses this addition has been purified from extracts of C. butyricum4,5 The vinyl ether-linked, aldehydogenic chains in C. butyricum plasmalogens can be derived from exogenous fatty acids and fatty acid precursors, presumably by way of the normal pathways for fatty acid synthesis2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Goldfine, H., J. Biol. Chem., 239, 2130 (1964).

    CAS  PubMed  Google Scholar 

  2. Baumann, N., Hagen, P-O., and Goldfine, H., J. Biol. Chem., 240, 1559 (1965).

    CAS  PubMed  Google Scholar 

  3. Zalkin, H., Law, J. H., and Goldfine, H., J. Biol. Chem., 238, 1242 (1963).

    CAS  PubMed  Google Scholar 

  4. Chung, A. E., and Law, J. H., Biochemistry, 3, 967 (1964).

    Article  CAS  PubMed  Google Scholar 

  5. Chung, A. E., and Law, J. H., Biochemistry, 3, 1989 (1964).

    Article  CAS  PubMed  Google Scholar 

  6. Renkonen, O., Acta Chem. Scand., 17, 634 (1963).

    Article  CAS  Google Scholar 

  7. Williams, jun., J. N., Anderson, C. E., and Jasik, A. D., J. Lipid Res., 3, 378 (1962).

    CAS  Google Scholar 

  8. Fleischer, S., and Klouwen, H., Biochem. Biophys. Res. Comm., 5, 378 (1961).

    Article  CAS  Google Scholar 

  9. Folch, J., Lees, M., and Sloane-Stanley, G. H., J. Biol. Chem., 226, 497 (1957).

    CAS  PubMed  Google Scholar 

  10. Farquhar, J. W., J. Lipid Res., 3, 21 (1962).

    CAS  Google Scholar 

Download references

Author information

Author notes

  1. ALBERT E. CHUNG

    Present address: University of Colorado, Department of Biochemistry, School of Medicine, Denver, Colorado

Authors and Affiliations

  1. Department of Chemistry, Harvard University, Cambridge, Massachusetts

    ALBERT E. CHUNG

  2. Department of Bacteriology and Immunology, Harvard Medical School, Boston, 15, Massachusetts

    HOWARD GOLDFINE

Authors
  1. ALBERT E. CHUNG
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HOWARD GOLDFINE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHUNG, A., GOLDFINE, H. Enzymatic Synthesis of Cyclo propane Fatty Aldehydes. Nature 206, 1253–1254 (1965). https://doi.org/10.1038/2061253c0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2061253c0

  • Springer Nature Limited

Search

Navigation