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Effects of Noradrenaline and Isoprenaline on the Permeability of Depolarized Intestinal Smooth Muscle to Inorganic Ions

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Abstract

IT has recently been shown1,2 that stimulation of the intrinsic inhibitory nerves of the guinea-pig taenia coli can cause a transient increase in the membrane potential of the smooth muscle cells. The magnitude of the hyperpolarization was found to vary with the external potassium concentration in a way which suggested that the transmitter, almost certainly largely noradrenaline, acts by increasing the permeability of the membrane to potassium ions. According to another hypothesis3,4, adrenaline, and presumably noradrenaline, can hyperpolarize the membrane by stimulating electrogenic extrusion of sodium from the cells.

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Authors and Affiliations

  1. Department of Pharmacology, University College, London,

    D. H. JENKINSON & I. K. M. MORTON

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  1. D. H. JENKINSON
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  2. I. K. M. MORTON
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JENKINSON, D., MORTON, I. Effects of Noradrenaline and Isoprenaline on the Permeability of Depolarized Intestinal Smooth Muscle to Inorganic Ions. Nature 205, 505–506 (1965). https://doi.org/10.1038/205505a0

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