Abstract
AMMONIA is required for the synthesis of carbamyl phosphate and hence of urea; but its origin has remained obscure. It has been generally suggested1, 2 that it could arise from various amino-acids by trans-de-amination through glutamate: amino-acid + α-oxoglutarate → α-keto acid + glutamate glutamate + NAD(P) + H2O → α-oxoglutarate + NH3 + NAD(P)H2
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HIRD, F., MARGINSON, M. Formation of Ammonia from Glutamate by Mitochondria. Nature 201, 1224–1225 (1964). https://doi.org/10.1038/2011224a0
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DOI: https://doi.org/10.1038/2011224a0
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