Skip to main content
SpringerLink
Log in

Immunotolerance to Heterologous Heart in the Rat

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

WHILE seeking to demonstrate the organ specificity of cardiac tissue1,2, an attempt was made to produce a specific antiserum in the rats using the phenomena of immunotolerance3,4. New-born rats received 18 daily intraperitoneal injections of homogenates of pooled organs (lung, liver, spleen, kidney and serum) of bovines, rabbits or guinea pigs during 3 weeks, followed by 3 weekly injections, a total of 220–250 mg protein being given to each rat. Other groups were given homogenate of heart or of heart and organ-pool and an untreated control group was included in each series.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Davies, A. M., and Gery, I., Amer. Heart J., 60, 669 (1960).

    Article  CAS  Google Scholar 

  2. Gery, I., and Davies, A. M., J. Immunol., 87, 351 and 357 (1961).

    CAS  PubMed  Google Scholar 

  3. Medawar, P. B., Fol. Biol. (Praha), 7, 1 (1961).

    Google Scholar 

  4. Feldman, M., and Yaffe, D., Nature, 179, 1353 (1957).

    Article  ADS  CAS  Google Scholar 

  5. Carter, B. G., and Cinader, B., Transplant. Bull., 7, 448 (1960).

    Google Scholar 

  6. Wozniczko-Orlowaka, G., Fol. Biol. (Praha), 7, 436 (1961).

    Google Scholar 

  7. Cinader, B., Nature, 188, 619 (1960).

    Article  ADS  CAS  Google Scholar 

  8. Owen, R. D., Proc. Roy. Soc., B., 146, 8 (1957).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Preventive Medicine, Hebrew University–Hadassah Medical School, Jerusalem

    A. MICHAEL DAVIES & IGAL GERY

Authors
  1. A. MICHAEL DAVIES
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. IGAL GERY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DAVIES, A., GERY, I. Immunotolerance to Heterologous Heart in the Rat. Nature 196, 184–185 (1962). https://doi.org/10.1038/196184a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/196184a0

  • Springer Nature Limited

Search

Navigation