Skip to main content
SpringerLink
Log in

Clinical Application of a Serological Method for the Determination of Human Chorionic Gonadotrophin

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

IT was early observed that prolonged administration to animals of gonadotrophic hormone from human pregnancy urine was accompanied by gradually diminished effects1. This phenomenon has been found to be due to the formation of an antigonadotrophic factor demonstrable only by its capacity to impair the gonadotrophic reaction in rodents2. Previous to our earlier report3, there had been no demonstration of the antigonadotrophic factor by serological in vitro methods. Precipitating and complement-fixing antibodies had been obtained by immunization of rabbits with gonadotrophic hormone prepared from human pregnancy urine4,5. These antibodies, however, were shown to be due to contaminating, antigenically active substances6.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Zondek, B., Hormone d. Ovariums u. d. Hypophysenvorderlappens, (Berlin and Vienna, 1931).

  2. Zondek, B., and Sulman, F., Proc. Soc. Exp. Biol. (N.Y.), 36, 708 (1937).

    Article  CAS  Google Scholar 

  3. Brody, S., and Carlström, G., Lancet, ii, 99 (1960).

  4. Bachman, C., Proc. Soc. Exp. Biol. (N.Y.), 32, 851 (1935).

    Article  CAS  Google Scholar 

  5. Twombly, G. H., Endocrinol., 20, 311 (1936).

    Article  CAS  Google Scholar 

  6. van den Ende, M., J. Endocrinol., 1, 156 (1939).

    Article  CAS  Google Scholar 

  7. McKean, C. M., Amer. J. Obstet. Gynec., 80, 596 (1960).

    Article  Google Scholar 

  8. Wide, L., and Gemzell, C. A., Acta Endocrinol. (Copenhagen), 35, 261 (1960).

    Article  CAS  Google Scholar 

  9. Fulton, F., and Dumbell, J. R., J. Gen. Microbiol., 3, 97 (1949).

    Article  CAS  Google Scholar 

  10. Svedmyr, A., Enders, J. F., and Holloway, A., Proc. Soc. Exp. Biol. (N.Y.), 79, 296 (1952).

    Article  CAS  Google Scholar 

  11. Friedman, M. H., Amer. J. Physiol., 90, 617 (1929).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynæcology, Karolinska Sjukhuset,

    SAM BRODY

  2. Gustaf Vth Research Institute, Stockholm

    SAM BRODY

  3. Department of Virus Research, Karolinska Institutet,

    GUN CARLSTRÖM

  4. Department of Bacteriology, Karolinska Sjukhuset, Stockholm

    GUN CARLSTRÖM

Authors
  1. SAM BRODY
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. GUN CARLSTRÖM
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BRODY, S., CARLSTRÖM, G. Clinical Application of a Serological Method for the Determination of Human Chorionic Gonadotrophin. Nature 189, 841–842 (1961). https://doi.org/10.1038/189841a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/189841a0

  • Springer Nature Limited

This article is cited by

Search

Navigation