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Dose–Response Relationship in Radiation Carcinogenesis

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Abstract

THE question whether the dose–response relationship for neoplasia induced by ionizing radiations is linear or non-linear, and with or without a threshold dose, is one of the most important problems in both basic and applied radiobiology1.

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References

  1. Report of the United Nations Scientific Committee on the Efects of Atomic Radiation (New York, 1958).

  2. Huxley, “Biological Aspects of Cancer” (Allen and Unwin, London, 1958). Boyland, ed., Brit. Med. Bull., 14, No. 2 (1958). Strong, ed., Ann. New York Acad. Sci., 71, Art. 6 (1958). Wolstenholme and O'Connor, ed., “CIBA Fondation Symposium on Carcinogenesis. Mechanisms of Action” (Churchill, London, 1959). Levan, Statens Naturvetenskapliga Forskningsråds Åsbok, 12, 212 (Stockholm, 1959). Bayreuther, K., Nature, 186, 6 (1960).

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  3. Arley and Iversen, Acta Path. Microbiol. Scand., 33, 133 (1953), see p. 143.

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  4. Mole, Brit. Med. Bull., 14, 188 (1958).

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  5. Bacq and Alexander, “Fundamentals of Radiobiology” (Butterworth, London, 1955); see especially Chapter 11.

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  6. Arley and Iversen, Nature, 169, 410 (1952). Iversen and Arley, ibid., 171, 257 (1953). Arley, Proc. Fourth Berkeley Symposium on Mathematical Statistics and Probability (Berkeley, in the press). Eker and Arley, “Adv. Biol. Med. Phys.” (in the press).

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Authors and Affiliations

  1. Norsk Hydro's Institute for Cancer Research, Radiumhospitalet, Norway

    NIELS ARLEY & REIDAR EKER

Authors
  1. NIELS ARLEY
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  2. REIDAR EKER
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ARLEY, N., EKER, R. Dose–Response Relationship in Radiation Carcinogenesis. Nature 189, 151–152 (1961). https://doi.org/10.1038/189151a0

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