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Phosphorylation as a Factor in promoting the Crabtree Effect in the Amytal Ascites Sarcoma of White Mice

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Abstract

CRABTREE1 has demonstrated an inhibition of oxygen consumption in several different malignant tissues following the addition of glucose. Many attempts have since been made, especially during recent years, to explain the mechanism of this phenomenon. Certain workers2,3 regard adenine nucleotides, others4,5 inorganic phosphorus, as responsible for the production of the Crabtree effect and postulate a competition between the oxidative and glycolytic systems for one of these substances. Åcs et al. 6 have suggested that a location of enzyme systems unique for the cells involved also plays some part in producing the inhibitory effect.

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References

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Authors and Affiliations

  1. Department of Pathology, Péterfy-S. Street Hospital, Budapest

    S. BRAUN, M. ERDÉLYI & A. UDVARDY

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  1. S. BRAUN
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  2. M. ERDÉLYI
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  3. A. UDVARDY
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BRAUN, S., ERDÉLYI, M. & UDVARDY, A. Phosphorylation as a Factor in promoting the Crabtree Effect in the Amytal Ascites Sarcoma of White Mice. Nature 188, 857–858 (1960). https://doi.org/10.1038/188857a0

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