Abstract
Grubb and Laurell1 and others have demonstrated that some human sera contain a genetically determined factor capable of inhibiting the ability of serum from selected rheumatoid arthritic patients (RA serum) to agglutinate Rh(+) cells coated with selected incomplete anti-D sera. They called this factor Gma and showed that its presence is due to a dominant gene. Thus far various investigators have tested 2,635 Europeans and found that 56.96 per cent were Gm(a+)2. Grubb and Laurell1 found 95 per cent of 74 Eskimos to be Gm(a+), and Steinberg and Giles2 found 98 per cent of 98 American Negroes to be Gm(a+).
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References
Grubb, R., and Laurell, A. B., Acta Path. Microb. Scand., 39, 390 (1956).
Reviewed in Steinberg, A. G., and Giles, Brenda Dawn, Amer. J. Human Genet. (in the press).
Harboe, M., and Lundevall, J., Acta Path. Microb. Scand., 45, 357 (1959).
Harboe, M., Nature, 183, 1468 (1959).
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STEINBERG, A., STAUFFER, R. & FUDENBERG, H. Distribution of Gma and Gm-like among Javanese, Djuka Negroes, and Oyana and Carib Indians. Nature 185, 324–325 (1960). https://doi.org/10.1038/185324a0
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DOI: https://doi.org/10.1038/185324a0
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