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Prevalence of gene polymorphisms associated with immune disorders in populations of Northern Eurasia

  • Genomics. Transcriptomics
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Abstract

Allele-frequency distributions for gene polymorphisms associated with autoimmune and allergic diseases, as well as the regulation of immunoglobulin E and cytokines levels, were studied in 26 populations of Northern Eurasia. There was no significant correlation between the values of average expected heterozygosity by 44 gene polymorphisms and climate or geographic factors. Population groups exhibited clustering according to their geographic location. The degree of genetic differentiation among populations and the selective neutrality of gene polymorphisms were also assessed. The results demonstrate substantial genetic diversity and differentiation of human populations by the genes studied.

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Authors and Affiliations

  1. National Research Tomsk State University, Tomsk, 634050, Russia

    A. A. Cherednichenko, E. A. Trifonova, K. V. Vagaitseva & V. A. Stepanov

  2. Research Institute for Medical Genetics, Tomsk, 634050, Russia

    A. A. Cherednichenko, E. A. Trifonova, K. V. Vagaitseva, A. V. Bocharova & V. A. Stepanov

  3. Chiril Draganiuc Institute of Phthisiopulmonology, Chisinau, MD 2025, Republic of Moldova

    A. M. Varzari

  4. Analytical Center for Collective Use, Dagestan Scientific Center, Russian Academy of Sciences, Makhachkala, 367001, Russia

    M. O. Radzhabov

  5. Dagestan Medical Dental Institute, Makhachkala, 367015, Russia

    M. O. Radzhabov

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  1. A. A. Cherednichenko
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  2. E. A. Trifonova
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  3. K. V. Vagaitseva
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Correspondence to A. A. Cherednichenko.

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Original Russian Text © A.A. Cherednichenko, E.A. Trifonova, K.V. Vagaitseva, A.V. Bocharova, A.M. Varzari, M.O. Radzhabov, V.A. Stepanov, 2015, published in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 6, pp. 984–992.

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Cherednichenko, A.A., Trifonova, E.A., Vagaitseva, K.V. et al. Prevalence of gene polymorphisms associated with immune disorders in populations of Northern Eurasia. Mol Biol 49, 881–889 (2015). https://doi.org/10.1134/S0026893315060047

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