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Measurement of a Staphylococcal Antibody in Human Serum by a Mouse Protection Test

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Abstract

THE need for a better understanding of immune phenomena related to staphylococcal infections has been repeatedly emphasized1. In so far as humoral antibodies are concerned, a substantial amount of work has been done only with staphylococcal antitoxins. However, as pointed out by Rountree and Barbour2, this approach has not appeared to be rewarding. It has also been suggested that anti-coagulase may be an important antibody3; but some doubt exists as to the significance of coagulase in staphylococcal infections4,5. Although a promising serological procedure was developed by Rountree and Barbour2, this method was not applied in a study of infections.

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FISHER, M. Measurement of a Staphylococcal Antibody in Human Serum by a Mouse Protection Test. Nature 183, 1692–1693 (1959). https://doi.org/10.1038/1831692a0

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