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Renewal of Bone Phosphate in Experimental Hyperparathyroidism

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Abstract

THE mode of action of parathyroid hormone is still obscure. The hormone seems, however, to exert its effect on calcium metabolism partly by a direct action on the bones1. Within a few hours profound changes appear in the bones of animals which have been given large doses of parathyroid extract2. The bone cells change their appearance and become dedifferentiated, that is, they do not reach full maturity functionally3. Concurrently there is a rapid resorption of mineral salts, the resorbed bone being replaced by fibrous tissue.

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Authors and Affiliations

  1. Department of Metabolic Research, Wenner-Gren Institute, Stockholm

    R. ZETTERSTRÖM & B. ENGFELDT

  2. Pathological Anatomy Department, Karolinska Institutet, Stockholm

    R. ZETTERSTRÖM & B. ENGFELDT

Authors
  1. R. ZETTERSTRÖM
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  2. B. ENGFELDT
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ZETTERSTRÖM, R., ENGFELDT, B. Renewal of Bone Phosphate in Experimental Hyperparathyroidism. Nature 168, 81–82 (1951). https://doi.org/10.1038/168081a0

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