Skip to main content
SpringerLink
Log in

A Method for Determining the Ratio of the Michael is Constants of an Enzyme with Respect to Two Substrates

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE extension of the Michaelis–Menten theory to a mixture of two substrates and an enzyme which attacks both given by Thorn1 has also been worked out by us and appears in a publication now in the press2. We have given a method of obtaining the ratio of the Michaelis constants which is simpler than his. Using Thorn's symbols, his last equation but one simplifies to where Vm is the maximum initial velocity of the mixed substrates. This equation can be transformed into, the equation

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Thorn, M. B., Nature, 164, 27 (1949).

    Article  ADS  CAS  Google Scholar 

  2. Adams, D. H., and Whittaker, V. P., Biochim. et Biophys. Acta (in the press).

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Oxford. London Hospital, London, E.1

    V. P. WHITTAKER & D. H. ADAMS

Authors
  1. V. P. WHITTAKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. H. ADAMS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WHITTAKER, V., ADAMS, D. A Method for Determining the Ratio of the Michael is Constants of an Enzyme with Respect to Two Substrates. Nature 164, 315–316 (1949). https://doi.org/10.1038/164315a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/164315a0

  • Springer Nature Limited

Search

Navigation