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Pharmacological Activities in Different Rodent Species of d-Tubocurarine Chloride and the Dimethyl Ether of d-Tubocurarine Iodide

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Abstract

THE molecule of d-tubocurarine chloride contains two phenolic hydroxy groups as well as two methoxy groups attached to the aromatic nucleus1. The hydroxy groups can be alkylated ; when they are methylated, the resulting dimethyl ether differs in a striking way from d-tubocurarine chloride in its pharmacological properties2.

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Authors and Affiliations

  1. Pharmacological Laboratory,

    H. O. J. COLLIER & SHEILA K. PARIS

  2. Research Laboratory, Allen and Hanburys, Ltd., Ware

    L. I. WOOLF

Authors
  1. H. O. J. COLLIER
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  2. SHEILA K. PARIS
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  3. L. I. WOOLF
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COLLIER, H., PARIS, S. & WOOLF, L. Pharmacological Activities in Different Rodent Species of d-Tubocurarine Chloride and the Dimethyl Ether of d-Tubocurarine Iodide. Nature 161, 817–819 (1948). https://doi.org/10.1038/161817a0

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  • DOI: https://doi.org/10.1038/161817a0

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