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Synthesis and Anti-Ischemic Activity in Rats of Substituted N-Benzyl 1,2,5-Trimethyl-, 2,2,6,6-Tetramethylpiperidyl-, and Tropylamines

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Pharmaceutical Chemistry Journal Aims and scope

Series of benzylidene and benzyl derivatives of 1,2,5-trimethyl-, 2,2,6,6-tetramethylpiperidyl-, and tropylamines were synthesized and screened for anti-ischemic activity in rats. The lead compound was identified as 2,2,6,6-tetramethyl-N-(3,4,5-trimethoxybenzyl)piperidin-4-amine, the anti-ischemic activity of which was statistically significantly greater than that of the reference drug trimetazidine in a myocardial subendocardial ischemia model.

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Authors and Affiliations

  1. V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiiskaya St., Moscow, 125315, Russia

    L. M. Kostochka, S. A. Kryzhanovskii, I. B. Tsorin, M. B. Vititnova & V. N. Stolyaruk

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  1. L. M. Kostochka
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  2. S. A. Kryzhanovskii
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  3. I. B. Tsorin
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  4. M. B. Vititnova
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  5. V. N. Stolyaruk
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Corresponding author

Correspondence to L. M. Kostochka.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 53, No. 2, pp. 21 – 24, February, 2019.

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Kostochka, L.M., Kryzhanovskii, S.A., Tsorin, I.B. et al. Synthesis and Anti-Ischemic Activity in Rats of Substituted N-Benzyl 1,2,5-Trimethyl-, 2,2,6,6-Tetramethylpiperidyl-, and Tropylamines. Pharm Chem J 53, 113–117 (2019). https://doi.org/10.1007/s11094-019-01963-8

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  • DOI: https://doi.org/10.1007/s11094-019-01963-8

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