Abstract
We investigate the validity of a Markov approach for the motility of kinesin. We show in detail how the various mechanochemical states and reaction rates that are experimentally measured, can be used to create a Markov-chain model. We compare the performance of this model to motility data and we find global similarities in the load and ATP-concentration dependency of speed and mean run length. We also discuss the relation between the experimentally found stalling behavior and thermodynamic expectations. Finally, the Markov chain modelling provides a way to calculate the mean entropy production and the (power) efficiency.
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Maes, C., van Wieren, M.H. A Markov Model for Kinesin. Journal of Statistical Physics 112, 329–355 (2003). https://doi.org/10.1023/A:1023691923564
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DOI: https://doi.org/10.1023/A:1023691923564