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Studies in the Imidazole Series. 100. Synthesis of Derivatives of Imidazo[1,2-a]pyrimidine from 2-Aminopyrimidines, Methyl Aryl Ketones, and Halogens

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Abstract

We have synthesized imidazo[1,2-a]pyrimidine derivatives by reaction of 2-aminopyrimidines with methyl aryl ketones and halogens (bromine, iodine). Using bromine leads to formation of 6-bromo- and 3,6-dibromo-substituted 2-arylimidazo[1,2-a]pyrimidines.

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Authors and Affiliations

  1. Drug Chemistry Center/, All-Russian Scientific-Research Pharmaceutical Chemistry Institute, Moscow, 119815

    P. M. Kochergin

  2. Zaporozhe State Medical University, Zaporozhe, 330074, Ukraine

    I. A. Mazur, G. K. Rogul'chenko, E. V. Aleksandrova & B. E. Mandrichenko

Authors
  1. P. M. Kochergin
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  2. I. A. Mazur
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  3. G. K. Rogul'chenko
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  4. E. V. Aleksandrova
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  5. B. E. Mandrichenko
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Kochergin, P.M., Mazur, I.A., Rogul'chenko, G.K. et al. Studies in the Imidazole Series. 100. Synthesis of Derivatives of Imidazo[1,2-a]pyrimidine from 2-Aminopyrimidines, Methyl Aryl Ketones, and Halogens. Chemistry of Heterocyclic Compounds 36, 1437–1440 (2000). https://doi.org/10.1023/A:1017574413941

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  • DOI: https://doi.org/10.1023/A:1017574413941

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