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Down-shifting luminescence of water soluble NaYF4:Eu3+@Ag core-shell nanocrystals for fluorescence turn-on detection of glucose

水溶性NaYF4:Eu3+@Ag 核-壳纳米晶的下转换荧光及其在葡萄糖检测中的应用

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Abstract

Techniques for detecting glucose are developing at a breathtaking speed because diabetes mellitus can cause many serious complications, such as blindness, high blood pressure heart disease and kidney failure. Herein, water soluble NaYF4:Eu3+@Ag core-shell nanocrystals for glucose detection with lower detection limit have been successfully developed, using NaYF4:Eu3+ cores as the energy donors and Ag shells as the efficient quenchers through energy transfer. After immobilization of glucose oxidase (GOx) on the surface of NaYF4:Eu3+@Ag core-shell nanocrystals, the Ag shells can be decomposed in the presence of glucose, accompanied by down-shifting luminescence recovery. The limit of detection of NaYF4:Eu3+@Ag was 0.12 μmol L−1. Therefore, the NaYF4:Eu3+@Ag can be easily extended to the detection of a variety of H2O2-involved analytes.

摘要

糖尿病可引起许多严重的并发症, 例如失明, 血压心脏病和肾衰竭等. 因此, 葡萄糖检测技术正在以惊人的速度发展. 本文合成了水溶性的NaYF4:Eu3+@Ag核-壳纳米晶体, 通过能量转移, Ag壳层可以有效吸收NaYF4:Eu3+的能量, 导致Eu3+离子荧光淬灭. 在NaYF4:Eu3+@Ag核-壳纳米晶体的表面上固定葡萄糖氧化酶(GOx)后, 通过加入一定量的葡萄糖, Ag纳米粒子可以分解成Ag+, 并伴随着Eu3+的荧光恢复. 结果表明, 该葡萄糖检测方法具有非常低的检测限(0.12 μmol L−1).

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References

  1. Wang G, Peng Q, Li Y. Lanthanide-doped nanocrystals: synthesis, optical-magnetic properties, and applications. Acc Chem Res, 2011, 44: 322–332

    Article  Google Scholar 

  2. Wang F, Liu X. Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. Chem Soc Rev, 2009, 38: 976–989

    Article  Google Scholar 

  3. Zhao P, Zhu Y, Yang X, et al. Plasmon-enhanced efficient dye-sensitized solar cells using core–shell-structured β-NaYF4:Yb,Er@SiO2@Au nanocomposites. J Mater Chem A, 2014, 2: 16523–16530

    Article  Google Scholar 

  4. Deng M, Tu N, Bai F, et al. Surface functionalization of hydrophobic nanocrystals with one particle per micelle for bioapplications. Chem Mater, 2012, 24: 2592–2597

    Article  Google Scholar 

  5. Wang H, Wang L. One-pot syntheses and cell imaging applications of poly(amino acid) coated LaVO4:Eu3+ luminescent nanocrystals. Inorg Chem, 2013, 52: 2439–2445

    Article  Google Scholar 

  6. Wang G, Peng Q, Li Y. Upconversion luminescence of monodisperse CaF2:Yb3+/Er3+ nanocrystals. J Am Chem Soc, 2009, 131: 14200–14201

    Article  Google Scholar 

  7. Xia Z, Liu Q. Progress in discovery and structural design of color conversion phosphors for LEDs. Prog Mater Sci, 2016, 84: 59–117

    Article  Google Scholar 

  8. Yu M, Su J, Wang G, et al. Pt/Y2O3:Eu3+ composite nanotubes: enhanced photoluminescence and application in dye-sensitized solar cells. Nano Res, 2016, 9: 2338–2346

    Article  Google Scholar 

  9. Palanisamy S, Zhang X, He T. Simple colorimetric detection of dopamine using modified silver nanoparticles. Sci China Chem, 2016, 59: 387–393

    Article  Google Scholar 

  10. Zhu W, Dong H, Zhen Y, et al. Challenges of organic “cocrystals”. Sci China Mater, 2015, 58: 854–859

    Article  Google Scholar 

  11. Luo W, Liu Y, Chen X. Lanthanide-doped semiconductor nanocrystals: electronic structures and optical properties. Sci China Mater, 2015, 58: 819–850

    Article  Google Scholar 

  12. Xie X, Liu X. Photonics: upconversion goes broadband. NatMater, 2012, 11: 842–843

    Google Scholar 

  13. Wang Y, Nan F, Cheng Z, et al. Strong tunability of cooperative energy transfer in Mn2+-doped (Yb3+, Er3+)/NaYF4 nanocrystals by coupling with silver nanorod array. Nano Res, 2015, 8: 2970–2977

    Article  Google Scholar 

  14. Shi F, Wang J, Zhai X, et al. Facile synthesis of β-NaLuF4: Yb/Tm hexagonal nanoplates with intense ultraviolet upconversion luminescence. CrystEngComm, 2011, 13: 3782–3787

    Article  Google Scholar 

  15. Krämer KW, Biner D, Frei G, et al. Hexagonal sodium yttrium fluoride based green and blue emitting upconversion phosphors. Chem Mater, 2004, 16: 1244–1251

    Article  Google Scholar 

  16. Wang M, Li M, Yang M, et al. NIR-induced highly sensitive detection of latent fingermarks by NaYF4:Yb,Er upconversion nanoparticles in a dry powder state. Nano Res, 2015, 8: 1800–1810

    Article  Google Scholar 

  17. Kong L, Ren Z, Zheng N, et al. Interconnected 1D Co3O4 nanowires on reduced graphene oxide for enzymeless H2O2 detection. Nano Res, 2015, 8: 469–480

    Article  Google Scholar 

  18. Guo GM, Wang XD, Zhou TY, et al. Extended detection range for an optical enzymatic glucose sensor coupling with a novel dataprocessing method. Sci China Chem, 2010, 53: 1385–1390

    Article  Google Scholar 

  19. Sanz V, de Marcos S, Castillo JR, et al. Application of molecular absorption properties of horseradish peroxidase for self-indicating enzymatic interactions and analytical methods. J Am Chem Soc, 2005, 127: 1038–1048

    Article  Google Scholar 

  20. Chen S, Hai X, Chen XW, et al. In situ growth of silver nanoparticles on graphene quantum dots for ultrasensitive colorimetric detection of H2O2 and glucose. Anal Chem, 2014, 86: 6689–6694

    Article  Google Scholar 

  21. Chen Q, Liu M, Zhao J, et al. Water-dispersible silicon dots as a peroxidase mimetic for the highly-sensitive colorimetric detection of glucose. Chem Commun, 2014, 50: 6771–6774

    Article  Google Scholar 

  22. Wang J. Electrochemical glucose biosensors. Chem Rev, 2008, 108: 814–825

    Article  Google Scholar 

  23. Shen P, Xia Y. Synthesis-modification integration: one-step fabrication of boronic acid functionalized carbon dots for fluorescent blood sugar sensing. Anal Chem, 2014, 86: 5323–5329

    Article  Google Scholar 

  24. Lan D, Li B, Zhang Z. Chemiluminescence flow biosensor for glucose based on gold nanoparticle-enhanced activities of glucose oxidase and horseradish peroxidase. Biosens Bioelectron, 2008, 24: 934–938

    Article  Google Scholar 

  25. Bostick DT, Hercules DM. Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol. Anal Chem, 1975, 47: 447–452

    Article  Google Scholar 

  26. Yang D, Li C, Li G, et al. Colloidal synthesis and remarkable enhancement of the upconversion luminescence of BaGdF5:Yb3+/Er3+ nanoparticles by active-shell modification. J Mater Chem, 2011, 21: 5923–5927

    Article  Google Scholar 

  27. Mai HX, Zhang YW, Sun LD, et al. Highly efficient multicolor up-conversion emissions and their mechanisms of monodisperse NaYF4:Yb,Er core and core/shell-structured nanocrystals. J Phys Chem C, 2007, 111: 13721–13729

    Article  Google Scholar 

  28. Yuan J, Cen Y, Kong XJ, et al. MnO2-nanosheet-modified upconversion nanosystem for sensitive turn-on fluorescence detection of H2O2 and glucose in blood. ACS Appl Mater Interfaces, 2015, 7: 10548–10555

    Article  Google Scholar 

  29. Wang F, Liu X. Upconversion multicolor fine-tuning: visible to near-infrared emission from lanthanide-doped NaYF4 nanoparticles. J Am Chem Soc, 2008, 130: 5642–5643

    Article  Google Scholar 

  30. Wang G, Peng Q, Li Y. Luminescence tuning of upconversion nanocrystals. Chem- A Eur J, 2010, 16: 4923–4931

    Article  Google Scholar 

  31. Lei S, Wang F, Li W, et al. Reversible wettability between superhydrophobicity and superhydrophilicity of Ag surface. Sci China Mater, 2016, 59: 348–354

    Article  Google Scholar 

  32. Duan C, Ren B, Liu H, et al. Flexible SERS active detection from novel Ag nano-necklaces as highly reproducible and ultrasensitive tips. Sci China Mater, 2016, 59: 435–443

    Article  Google Scholar 

  33. Wang M, Meng G, Huang Q, et al. CNTs-anchored egg shell membrane decorated with Ag-NPs as cheap but effective SERS substrates. Sci China Mater, 2015, 58: 198–203

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Natural Science Foundation of China (21471050 and 21501052), the China Postdoctoral Science Foundation (2015M570304), the Postdoctoral Science Foundation of Heilongjiang Province (LBH-TZ06019), the Natural Science Foundation of Heilongjiang Province (ZD201301d), and the Science Foundation for Excellent Youth of Harbin City of China (2016RQQXJ099).

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Authors and Affiliations

  1. Key Laboratory of Functional Inorganic Materials Chemistry (Ministry of Education), School of Chemistry and Materials Science, Heilongjiang University, Harbin, 150080, China

    Di Wang  (王迪), Ruihong Wang  (王瑞红), Liyuan Liu  (刘丽娟), Yang Qu  (曲阳) & Guofeng Wang  (王国凤)

  2. Department of Chemistry, Tsinghua University, Beijing, 100084, China

    Yadong Li  (李亚栋)

Authors
  1. Di Wang  (王迪)
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  2. Ruihong Wang  (王瑞红)
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  3. Liyuan Liu  (刘丽娟)
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  4. Yang Qu  (曲阳)
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  5. Guofeng Wang  (王国凤)
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  6. Yadong Li  (李亚栋)
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Correspondence to Guofeng Wang  (王国凤).

Additional information

Di Wang is currently a master candidate at Heilongjiang University. She joined Professor GuofengWang’s research group in 2015, mainly working on the synthesis and application of Ln3+-doped nanocrystals.

Guofeng Wang is a professor at the Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education, School of Chemistry and Materials Science, Heilongjiang University. Her current research is focused on the synthesis and application of Ln3+-doped nanocrystals.

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40843_2016_5145_MOESM1_ESM.pdf

Down-shifting luminescence of water soluble NaYF4:Eu3+@Ag core-shell nanocrystals for fluorescence turn-on detection of glucosen

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Wang, D., Wang, R., Liu, L. et al. Down-shifting luminescence of water soluble NaYF4:Eu3+@Ag core-shell nanocrystals for fluorescence turn-on detection of glucose. Sci. China Mater. 60, 68–74 (2017). https://doi.org/10.1007/s40843-016-5145-1

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