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Hypovitaminosis D is associated with endothelial dysfunction in patients with non-dialysis chronic kidney disease

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Abstract

Objective

Cardiovascular events are highly prevalent in chronic kidney disease (CKD). Hypovitaminosis D and vascular endothelial dysfunction are risk factors for cardiovascular morbidity and mortality and they both are common in CKD patients. This study aimed to investigate the association between hypovitaminosis D and endothelial dysfunction in non-dialysis CKD patients.

Methods

In 117 non-dialysis CKD patients, we assessed endothelial function by brachial artery flow-mediated dilation (FMD), soluble vascular cell adhesion molecule-1 (sVCAM-1) and sE-selectin. 25-hydroxyvitamin D [25(OH)D] was measured by electrochemiluminescence immunoassay.

Results

Brachial artery FMD was lower in vitamin D-deficient and -insufficient versus vitamin D-sufficient groups, with the lowest value observed in the vitamin D-deficient group. Conversely, sVCAM-1 and sE-selectin were higher in vitamin D-deficient and -insufficient groups versus vitamin D-sufficient, and the highest value was observed in the vitamin D-deficient group. There was a positive association between FMD and 25(OH)D (r = 0.556, p < 0.001) and negative correlations between both sVCAM-1 (r = −0.549, p < 0.001) and sE-selectin (r = −0.360, p < 0.001) and 25(OH)D. These associations remained significant after adjusting for confounders.

Conclusions

Hypovitaminosis D is associated with endothelial dysfunction in non-dialysis CKD patients. Further studies are needed to confirm whether vitamin D supplementation can improve endothelial function and reduce cardiovascular events in these patients.

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Acknowledgments

This study was supported by the Fundamental Research Funds for the Central Universities (Program No. 021414340339).

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Nephrology, Affiliated Drum Tower Hospital, Medical School of Nanjing University, 321 Zhong Shan Road, Nanjing, 210008, China

    Qing-yan Zhang, Chun-ming Jiang, Cheng Sun, Tian-feng Tang, Bo Jin, Dong-wei Cao, Jing-song He & Miao Zhang

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  1. Qing-yan Zhang
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  2. Chun-ming Jiang
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  3. Cheng Sun
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  4. Tian-feng Tang
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  7. Jing-song He
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  8. Miao Zhang
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Correspondence to Miao Zhang.

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Zhang, Qy., Jiang, Cm., Sun, C. et al. Hypovitaminosis D is associated with endothelial dysfunction in patients with non-dialysis chronic kidney disease. J Nephrol 28, 471–476 (2015). https://doi.org/10.1007/s40620-014-0167-8

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  • DOI: https://doi.org/10.1007/s40620-014-0167-8

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