Abstract
Background
Renal function (RF) and activities of daily living (ADL) are risk factors for heart failure (HF) patients.
Aims
We evaluated differences in motor and cognitive ADL in relation to RF in elderly hospitalized HF patients.
Methods
Participants were selected from 414 consecutive hospitalized HF patients based on certain criteria. We investigated patient characteristics including Functional Independence Measure (FIM) and estimated glomerular filtration rate (eGFR). Subjects were divided into three groups by RF level and analyzed with one-way ANOVA and Chi-square tests and two-way ANCOVA and multiple comparison tests.
Results
Of the 414 patients, 165 met the inclusion criteria (high RF: 41, moderate RF: 84, low RF: 40). There were significant differences between the three groups in age, eGFR, hemoglobin level, mobility, cognitive function, and length of hospital stay (p < 0.05). Motor FIM showed an interaction between term and group, and cognitive FIM showed a main effect on the group (p < 0.05). In the multiple comparisons, motor FIM of all groups indicated significant recovery, but it was significantly lower after 1 week in the low RF versus moderate/high RF groups (p < 0.05). Cognitive FIM showed no significant recovery in the low RF group; the FIM score after 2 weeks was significantly lower than that in the moderate/high RF groups (p < 0.05).
Conclusions
In elderly hospitalized HF patients, the motor ADL recovery process in the low RF group was delayed compared to the high RF group. Cognitive ADL in hospitalized HF patients is difficult to recover, especially in those with low RF.
Similar content being viewed by others
References
Kannel WB, Belanger AJ (1991) Epidemiology of heart failure. Am Heart J 121:951–957
Owan TE, Hodge DO, Herges RM et al (2006) Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355:251–259
Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S et al (2006) Clinical characteristics and outcome of hospitalized patients with heart failure in Japan. Circ J 70:1617–1623
Nohara R, Adachi H, Gotho Y et al (2014) Guidelines for rehabilitation in patients with cardiovascular disease. Circ J 78:2022–2093
Dunlay SM, Manemann SM, Chamberlain AM et al (2015) Activities of daily living and outcomes in heart failure. Circ Heart Fail 8:261–267
Hamaguchi S, Tsuchihashi-Makaya M, Kinugawa S et al (2009)Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan. Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). Circ J 73:1442–1447
Levey AS, Eckardt KU, Tsukamoto Y et al (2005) Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 67:2089–2100
Imai E, Horio M, Iseki K et al (2007) Prevalence of chronic kidney disease (CKD) in the Japanese general population predicted by the MDRD equation modified by a Japanese coefficient. Clin Exp Nephrol 11:156–163
Davies DF, Shock NW (1950) Age changes in glomerular filtration rate, effective renal plasma flow, and tubular excretory capacity in adult males. J Clin Invest 29:496–507
Hotta C, Hiraki K, Watanabe S et al (2011) Determinants of exercise capacity in chronic heart failure patients with chronic kidney disease. Rigakuryouhougaku 38:436–441 (in Japanese with English abstract)
Saitoh M, Itoh H, Morotomi N et al (2014) Impact of chronic kidney disease and anemia on physical function in patients with chronic heart failure. Cardiorenal Med 4:73–81
Wang H, Liu T, Cai YY et al (2016) Kidney function and cognitive impairment in people aged 80 years and over with untreated hypertension: a cross-sectional survey. Kidney Blood Press Res 41:70–77
Elias MF, Elias PK, Seliger SL et al (2009) Chronic kidney disease, creatinine and cognitive functioning. Nephrol Dial Transpl 24:2446–2452
Saitoh M, Ozawa T, Shiotani Y et al (2013) Effects of left ventricular systolic dysfunction and cardio-renal anemia syndrome on walking ability and activities of daily living in patients with heart failure. J Jpn Phys Ther Assoc 40:10–15 (in Japanese)
Kitamura M, Mimura Y, Taniue H et al (2016) Predictors of independent walking at hospital discharge in elderly heart failure patients. Int J Cardiol 203:609–611
Collen FM, Wade DT, Robb GF et al (1991) The Rivermead Mobility Index: a further development of the Rivermead Motor Assessment. Int Disabil Stud 13:50–54
Hakamata M, Saito K, Harada K et al (2011) Study of transitions of clinical symptoms before incidences of falls by older inpatients with dementia. Rigakuryoho Kagaku 26:641–646 (in Japanese)
Matsuo S, Imai E, Horio M et al (2009) Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 53:982–992
Matsushita K, Selvin E, Bash LD et al (2010) Coresh. Risk implications of the new CKD Epidemiology Collaboration (CKD-EPI) equation compared with the MDRD Study equation for estimated GFR: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 55:648–659
Imai E, Iseki K, Nitta K et al (2012) Clinical practice guidebook for diagnosis and treatment of chronic kidney disease 2012. Nihon Jinzo Gakkai Shi 1:1–4
Ottenbacher KJ, Hsu Y, Granger CV et al (1996) The reliability of the functional independence measure: a quantitative review. Arch Phys Med Rehabil 77:1226–1232
Astor BC, Muntner P, Levin A et al (2002) Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988–1994). Arch Intern Med 162:1401–1408
Go AS, Hylek EM, Phillips KA et al (2001) Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 285:2370–2375
Damman K, Navis G, Voors AA et al (2007) Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail 13:599–608
Adhiyaman V, Asghar M, Oke A et al (2001) Nephrotoxicity in the elderly due to co-prescription of angiotensin converting enzyme inhibitors and nonsteroidal anti-inflammatory drugs. J R Soc Med 94:512–514
Reid R, Ezekowitz JA, Brown PM et al (2015) The prognostic importance of changes in renal function during treatment for acute heart failure depends on admission renal function. PLoS One 10:e0138579. doi:10.1371/journal.pone.0138579
Palmer JB, Friedman HS, Waltman Johnson K et al (2015) Association of persistent and transient worsening renal function with mortality risk, readmissions risk, length of stay, and costs in patients hospitalized with acute heart failure. Clinicoecon Outcomes Res 7:357–367
Saltin B, Blomqvist G, Mitchell JH et al (1968) Response to exercise after bed rest and after training. Circulation 38:VII1–VII78
Izumi T, Isobe M, IthoH, Kitakaze M, Sawa Y, Seino Y, Tsutsui H, Hirayama A, Momomura S, Yamazaki K, JCS Joint Working Group (2013) Guidelines for treatment of acute heart failure (JCS 2011). Circ J 77:2157–2201
Llano-Diez M, Renaud G, Andersson M et al (2012) Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading. Crit Care 16:R209
Schweickert WD, Pohlman MC, Pohlman AS et al (2009) Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. The Lancet 373:1874–1882
Kitamura M, Saitoh K, Mizutani A et al (2016) Recovery process of mobility and prognosis of walking independence in elderly patients with heart failure. Rigakuryouhougaku 43:47–55 (in Japanese)
Plantinga LC, Johansen K, Crews DC et al (2011) Association of CKD with disability in the United States. Am J Kidney Dis 57:212–227
Hiraki K, Yasuda T, Hotta C et al (2013) Decreased physical function in pre-dialysis patients with chronic kidney disease. Clin Exp Nephrol 17:225–231
Onem Y, Terekeci H, Kucukardali Y et al (2010) Albumin, hemoglobin, body mass index, cognitive and functional performance in elderly persons living in nursing homes. Arch Gerontol Geriatr 50:56–59
Gupta T, Paul N, Kolte D et al (2015) Association of chronic renal insufficiency with in-hospital outcomes after percutaneous coronary intervention. J Am Heart Assoc 4:6
Hopkins RO, Weaver LK, Collingridge D et al (2005) Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 171:340–347
Hopkins RO, Jackson JC (2006) Long-term neurocognitive function after critical illness. Chest 130:869–878
Sukantarat KT, Burgess PW, Williamson RC et al (2005) Prolonged cognitive dysfunction in survivors of critical illness. Anaesthesia 60:847–853
Brummel NE, Girard TD, Ely EW et al (2014) Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med 40:370–379
Darsie B, Shlipak MG, Sarnak MJ et al (2014) Kidney function and cognitive health in older adults: the Cardiovascular Health Study. Am J Epidemiol 180:68–75
Pulignano G, Del Sindaco D, Di Lenarda A et al (2014) Chronic renal dysfunction and anaemia are associated with cognitive impairment in older patients with heart failure. J Cardiovasc Med (Hagerstown) 15:481–490
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The participants received oral explanations of the research procedures from the researchers.
Conflict of interest
There are no conflicts of interest to report in relation to this study.
Ethical approval
This study was approved by the Kokura Rehabilitation College Institutional Committee.
Informed consent
Informed consent was obtained from each patient.
Rights and permissions
About this article
Cite this article
Kitamura, M., Izawa, K.P., Taniue, H. et al. Activities of daily living at different levels of renal function in elderly hospitalized heart failure patients. Aging Clin Exp Res 30, 45–51 (2018). https://doi.org/10.1007/s40520-017-0739-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40520-017-0739-2