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A Review on Sporotrichosis and the Emergence of Sporothrix brasiliensis as a Pathogen

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Abstract

Purpose of Review

This review explores sporotrichosis development as a disease in both cats and humans as well as options for diagnosis and treatment. This work also discusses the factors that might have culminated on the emergence of Sporothrix brasiliensis as the main etiological agent of this disease.

Recent Findings

Sporotrichosis is currently an epidemic in Brazil with cats acting as the primary vector of the disease. And, although molecular diagnostic techniques have been recently developed, the disease remains largely unchecked evidencing the need for novel therapeutic options as well as a more effective public health response.

Summary

It is becoming more evident that to manage and control sporotrichosis, a One Health approach needs to be globally adopted. In addition to that, global warming is creating increasingly favorable conditions to the emergence of fungal pathogens.

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Data Availability

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Rossow JA, Queiroz-Telles F, Caceres DH, Beer KD, Jackson BR, Pereira JG, Ferreira Gremião ID, Pereira SA. A One Health approach to combatting Sporothrix brasiliensis: narrative review of an emerging zoonotic fungal pathogen in South America. J Fungi. 2020;6:247.

    Article  CAS  Google Scholar 

  2. Rodrigues AM, Hagen F, de Camargo ZP. A spotlight on Sporothrix and sporotrichosis. Mycopathologia. 2022;187:407–11.

    Article  PubMed  Google Scholar 

  3. Rodrigues AM, de Melo TM, de Hoog GS, Schubach TMP, Pereira SA, Fernandes GF, Bezerra LML, Felipe MS, de Camargo ZP. Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks. PLoS Negl Trop Dis. 2013;7: e2281.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Alvarez CM, Oliveira MME, Pires RH. Sporotrichosis: a review of a neglected disease in the last 50 years in Brazil. Microorganisms. 2022;10:2152.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Moussa TAA, Kadasa NMS, Al Zahrani HS, et al. Origin and distribution of Sporothrix globosa causing sapronoses in Asia. J Med Microbiol. 2017;66:560–9.

    Article  PubMed  Google Scholar 

  6. Zhang Y, Hagen F, Stielow B, et al. Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animal case reports. Persoonia. 2015;35:1–20.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Barros MBL, Schubach AO, Schubach TMP, Wanke B, Lambert-Passos SR. An epidemic of sporotrichosis in Rio de Janeiro, Brazil: epidemiological aspects of a series of cases. Epidemiol Infect. 2008;136:1192–6.

    Article  PubMed  CAS  Google Scholar 

  8. Rodrigues AM, Gonçalves SS, de Carvalho JA, Borba-Santos LP, Rozental S, Camargo ZP de. Current progress on epidemiology, diagnosis, and treatment of sporotrichosis and their future trends. J Fungi Basel Switz. 2022;8:776. In this work, Rodrigues and colleagues provide a in depth review of sporotrichosis epidemiology, diagnosis and treatment. They also discuss potential developments of the sporothrix-sporotrichosis system and some of the ways that the disease could be mitigated.

  9. Izoton CFG, de Brito Sousa AX, Valete CM, et al. Sporotrichosis in the nasal mucosa: a single-center retrospective study of 37 cases from 1998 to 2020. PLoS Negl Trop Dis. 2023;17: e0011212.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. Bittencourt AA, Oyafuso LKM, Cavalin RF, et al. A neglected disease. Human sporotrichosis in a densely populated urban area in São Paulo, Brazil: clinical–epidemiological and therapeutic aspects. Braz J Microbiol. 2022;53:739–48.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  11. Gremião IDF, Miranda LHM, Reis EG, Rodrigues AM, Pereira SA. Zoonotic epidemic of sporotrichosis: cat to human transmission. PLoS Pathog. 2017;13: e1006077.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Almeida-Paes R, de Oliveira MME, Freitas DFS, do Valle ACF, Zancopé-Oliveira RM, Gutierrez-Galhardo MC. Sporotrichosis in Rio de Janeiro, Brazil: Sporothrixbrasiliensis is associated with atypical clinical presentations. PLoS Negl Trop Dis. 2014;8:e3094.

  13. Gonzalez Cabo JF, de las Heras Guillamon M, Latre Cequiel MV, Garcia de Jalon Ciercoles JA. Feline sporotrichosis: a case report. Mycopathologia. 1989;108:149–154.

  14. Hirano M, Watanabe K, Murakami M, Kano R, Yanai T, Yamazoe K, Fukata T, Kudo T. A case of feline sporotrichosis. J Vet Med Sci. 2006;68:283–4.

    Article  PubMed  Google Scholar 

  15. Scheufen S, Strommer S, Weisenborn J, Prenger-Berninghoff E, Thom N, Bauer N, Köhler K, Ewers C. Clinical manifestation of an amelanotic Sporothrix schenckii complex isolate in a cat in Germany. JMM Case Rep. 2015;2: e000039.

    Article  Google Scholar 

  16. Falcão EMM, Pires MC de S, Andrade HB, Gonçalves MLC, Almeida-Paes R, do Valle ACF, Bastos FI, Gutierrez-Galhardo MC, Freitas DFS. Zoonotic sporotrichosis with greater severity in Rio de Janeiro, Brazil: 118 hospitalizations and 11 deaths in the last 2 decades in a reference institution. Med Mycol. 2020;58:141–143. In this work, Falcão and colleagues provide a portrait of the development of sporotrichosis in Rio de Janeiro, the area most affected by the disease, in the last two decades. This retrospective search in INI/Fiocruz database, an internationally recognized reference institution, provides valuable insight of the epidemiology of the disease.

  17. Barros MB de L, de Almeida Paes R, Schubach AO. Sporothrix schenckii and sporotrichosis. Clin Microbiol Rev. 2011;24:633–654.

  18. Hay RJ, Morris-Jones R. Outbreaks of sporotrichosis. Curr Opin Infect Dis. 2008;21:119–21.

    Article  PubMed  Google Scholar 

  19. Etchecopaz A, Toscanini MA, Gisbert A, Mas J, Scarpa M, Iovannitti CA, Bendezú K, Nusblat AD, Iachini R, Cuestas ML. Sporothrix brasiliensis: a review of an emerging South American fungal pathogen, its related disease, presentation and spread in Argentina. J Fungi Basel Switz. 2021;7:170.

    Article  CAS  Google Scholar 

  20. Barros MB de L, Schubach TP, Coll JO, Gremião ID, Wanke B, Schubach A. Esporotricose: a evolução e osdesafios de uma epidemia. Rev Panam Salud Pública. 2010;27:455–460.

  21. Gremião IDF, Oliveira MME, Monteiro de Miranda LH, Saraiva Freitas DF, Pereira SA. Geographic expansion of sporotrichosis, Brazil. Emerg Infect Dis. 2020;26:621–4.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Barnacle JR, Chow YJ, Borman AM, Wyllie S, Dominguez V, Russell K, Roberts H, Armstrong-James D, Whittington AM. The first three reported cases of Sporothrix brasiliensis cat-transmitted sporotrichosis outside South America. Med Mycol Case Rep. 2023;39:14–7.

    Article  PubMed  Google Scholar 

  23. Seyedmousavi S, Guillot J, Tolooe A, Verweij PE, de Hoog GS. Neglected fungal zoonoses: hidden threats to man and animals. Clin Microbiol Infect. 2015;21:416–25.

    Article  PubMed  CAS  Google Scholar 

  24. Rodrigues ML, Nosanchuk JD. Fungal diseases as neglected pathogens: a wake-up call to public health officials. PLoS Negl Trop Dis. 2020;14: e0007964.

    Article  PubMed  PubMed Central  Google Scholar 

  25. WHO fungal priority pathogens list to guide research, development and public health action. https://www.who.int/publications-detail-redirect/9789240060241. Accessed 23 May 2023.

  26. Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR. Fungi that infect humans. Microbiol Spectr. 2017. https://doi.org/10.1128/microbiolspec.FUNK-0014-2016.

    Article  PubMed  Google Scholar 

  27. Valdez AF, Miranda DZ, Guimarães AJ, Nimrichter L, Nosanchuk JD. Pathogenicity & virulence of Histoplasma capsulatum - a multifaceted organism adapted to intracellular environments. Virulence. 2022;13:1900–19.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Brilhante RSN, Fernandes MR, Pereira VS, et al. Biofilm formation on cat claws by Sporothrix species: an ex vivo model. Microb Pathog. 2021;150: 104670.

    Article  PubMed  CAS  Google Scholar 

  29. Freitas DFS, Santos SS, Almeida-Paes R, de Oliveira MME, do Valle ACF, Gutierrez-Galhardo MC, Zancopé-Oliveira RM, Nosanchuk JD. Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis. Virulence. 2015;6:112–120.

  30. Oliveira MME, Almeida-Paes R, Corrêa-Moreira D, et al. A case of sporotrichosis caused by different Sporothrix brasiliensis strains: mycological, molecular, and virulence analyses. Mem Inst Oswaldo Cruz. 2019;114: e190260.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Corrêa-Junior D, de Andrade IB, Alves V, et al. Unveiling the morphostructural plasticity of zoonotic sporotrichosis fungal strains: possible implications for Sporothrix brasiliensis virulence and pathogenicity. J Fungi. 2023;9:701.

    Article  Google Scholar 

  32. Corrêa-Junior D, de Andrade IB, Alves V, et al. Metabolic plasticity and virulence-associated factors of Sporothrix brasiliensis strains related to familiar outbreaks of cat-to-human transmitted sporotrichosis. J Fungi Basel Switz. 2023;9:724.

    Article  Google Scholar 

  33. Rabello VBS, Almeida-Silva F, Scramignon-Costa B de S, Motta B da S, de Macedo PM, Teixeira M de M, Almeida-Paes R, Irinyi L, Meyer W, Zancopé-Oliveira RM. Environmental isolation of Sporothrix brasiliensis in an area with recurrent feline sporotrichosis cases. Front Cell Infect Microbiol. 2022;12:894297.

  34. Garcia-Solache MA, Casadevall A. Global warming will bring new fungal diseases for mammals. mBio. 2010;1:e00061–10.

  35. Casadevall A. Fungal virulence, vertebrate endothermy, and dinosaur extinction: is there a connection? Fungal Genet Biol FG B. 2005;42:98–106.

    Article  PubMed  Google Scholar 

  36. Bergman A, Casadevall A. Mammalian endothermy optimally restricts fungi and metabolic costs. mBio. 2010;1:e00212–10.

  37. Robert VA, Casadevall A. Vertebrate endothermy restricts most fungi as potential pathogens. J Infect Dis. 2009;200:1623–6.

    Article  PubMed  Google Scholar 

  38. Organization (WMO) WM, World Meteorological Organization (WMO). State of the climate in Latin America and the Caribbean 2021 (WMO-No. 1295). WMO, Geneva; 2022.

  39. Orofino-Costa R, Freitas DFS, Bernardes-Engemann AR, et al. Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management. An Bras Dermatol. 2022;97:757–777. In this work, Orofino-Costa and colleagues provide standardized recommendations for the therapeutic management, diagnosis and clinical aspect of sporotrichosis. These instructions were put together by a panel of twelve experts in human sporotrichosis from different Brazilian regions, divided by three different work groups: clinical, diagnosis and treatment.

  40. Alves M do M, Milan EP, Silva-Rocha WP da, et al. Fatal pulmonary sporotrichosis caused by Sporothrix brasiliensis in Northeast Brazil. PLoS Negl Trop Dis. 2020;14:e0008141.

  41. de Andrade Galliano Daros Bastos F, Raimundo Cognialli RC, Rodrigues de Farias M, Dos Santos Monti F, Wu K, Queiroz-Telles F. Spread of Sporothrix spp. through respiratory droplets from infected cats: a potential route of transmission. Med Mycol. 2022;60:myac079.

  42. Farooqui SM, Youness H. The infection returns: a case of pulmonary sporotrichosis relapse after chemotherapy. Case Rep Med. 2018;2018:1384029.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Rojas FD, Fernández MS, Lucchelli JM, Lombardi D, Malet J, Vetrisano ME, Cattana ME, Sosa M de LÁ, Giusiano G. Cavitary pulmonary sporotrichosis: case report and literature review. Mycopathologia. 2017;182:1119–1123.

  44. Yagnik KJ, Skelton WP, Olson A, Trillo CA, Lascano J. A rare case of disseminated Sporothrix schenckii with bone marrow involvement in a patient with idiopathic CD4 lymphocytopenia. IDCases. 2017;9:70–2.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Mahajan VK. Sporotrichosis: an overview and therapeutic options. Dermatol Res Pract. 2014;2014: 272376.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Casadevall A, Pirofski LA. Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity. Infect Immun. 1999;67:3703–13.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  47. García Carnero LC, Lozoya Pérez NE, González Hernández SE, Martínez Álvarez JA. Immunity and treatment of sporotrichosis. J Fungi Basel Switz. 2018;4:100.

    Article  Google Scholar 

  48. Rodriguez-Caban J, Gonzalez-Velazquez W, Perez-Sanchez L, Gonzalez-Mendez R, Rodriguez-del Valle N. Calcium/calmodulin kinase1 and its relation to thermotolerance and HSP90 in Sporothrix schenckii: an RNAi and yeast two-hybrid study. BMC Microbiol. 2011;11:162.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  49. Arrillaga-Moncrieff I, Capilla J, Mayayo E, Marimon R, Mariné M, Gené J, Cano J, Guarro J. Different virulence levels of the species of Sporothrix in a murine model. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis. 2009;15:651–5.

    CAS  Google Scholar 

  50. Tamez-Castrellón AK, Romeo O, García-Carnero LC, Lozoya-Pérez NE, Mora-Montes HM. Virulence factors in Sporothrix schenckii, one of the causative agents of sporotrichosis. Curr Protein Pept Sci. 2020;21:295–312.

    Article  PubMed  Google Scholar 

  51. Lopes-Bezerra LM, Schubach A, Costa RO. Sporothrix schenckii and sporotrichosis. An Acad Bras Cienc. 2006;78:293–308.

    Article  PubMed  Google Scholar 

  52. Freitas DFS, de Siqueira Hoagland B, do Valle ACF, et al. Sporotrichosis in HIV-infected patients: report of 21 cases of endemic sporotrichosis in Rio de Janeiro, Brazil. Med Mycol. 2012;50:170–178.

  53. Cruz ILR, Freitas DFS, de Macedo PM, et al. Evolution of virulence-related phenotypes of Sporothrix brasiliensis isolates from patients with chronic sporotrichosis and acquired immunodeficiency syndrome. Braz J Microbiol Publ Braz Soc Microbiol. 2021;52:5–18.

    Article  CAS  Google Scholar 

  54. Silva-Bailão MG, Lima P de S, Oliveira MME, Oliveira LC, Almeida-Paes R, Borges CL, Bailão AM, Coelho ASG, Soares CM de A, Zancopé-Oliveira RM. Comparative proteomics in the three major human pathogenic species of the genus Sporothrix. Microbes Infect. 2021;23:104762.

  55. Boechat JS, Oliveira MME, Almeida-Paes R, et al. Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area. Mem Inst Oswaldo Cruz. 2018;113:185–96.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  56. Carlos IZ, Batista-Duharte A. Sporotrichosis: an emergent disease. In: Zeppone Carlos I, editor. Sporotrichosis New Dev. Future Prospects. Springer International Publishing, Cham, 2015. pp 1–23.

  57. Schubach TMP, Schubach A de O, Okamoto T, et al. Sporothrix schenckii isolation from blood clot of naturally infected cats. Braz J Vet Res Anim Sci. 2004;41:404–408.

  58. Zancope-Oliveira RM, de Almeida-Paes R, de Oliveira MME, Freitas DFS, Galhardo MCG. New diagnostic applications in sporotrichosis. Skin Biopsy - Perspect. 2011. https://doi.org/10.5772/23590.

    Article  Google Scholar 

  59. Lopes-Bezerra LM, Mora-Montes HM, Zhang Y, Nino-Vega G, Rodrigues AM, de Camargo ZP, de Hoog S. Sporotrichosis between 1898 and 2017: the evolution of knowledge on a changeable disease and on emerging etiological agents. Med Mycol. 2018;56:126–43.

    Article  PubMed  Google Scholar 

  60. Baptista VS, Mothé GB, Santos GMP, et al. Promising application of the SsCBF ELISA test to monitor the therapeutic response of feline sporotrichosis caused by Sporothrix brasiliensis from Brazilian epidemics. Braz J Microbiol Publ Braz Soc Microbiol. 2021;52:145–53.

    Article  CAS  Google Scholar 

  61. Almeida-Paes R, Pimenta MA, Pizzini CV, Monteiro PCF, Peralta JM, Nosanchuk JD, Zancopé-Oliveira RM. Use of mycelial-phase Sporothrix schenckii exoantigens in an enzyme-linked immunosorbent assay for diagnosis of sporotrichosis by antibody detection. Clin Vaccine Immunol. 2007;14:244–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  62. BIDiagnostics - Sorodiagnóstico de doenças infecto-parasitárias. In: BIDiagnostics. https://bidiagnostics.com.br/. Accessed 24 May 2023.

  63. Almeida-Silva F, Almeida M de A, Rabello VB de S, et al. Evaluation of five non-culture-based methods for the diagnosis of meningeal sporotrichosis. J Fungi Basel Switz. 2023;9:535. Because meningeal sporotrichosis diagnosis from cerebrospinal fluid is usually hard due to the low fungal burden presented, Almeida-Silva and colleagues tested and discussed five non-culture-based methods for diagnosis. The authors discovered that four out of the five methods tested had substantial levels of sensitivity and specificity and suggest that these methods should be implemented as soon as possible into clinical practice to improve prognosis in these cases.

  64. Thomson P, González C, Blank O, Ramírez V, Río CD, Santibáñez S, Pena P. Sporotrichosis outbreak due to Sporothrix brasiliensis in domestic cats in Magallanes, Chile: a One-Health-approach study. J Fungi Basel Switz. 2023;9:226.

    Article  Google Scholar 

  65. Gremião IDF, da Silva M, da Rocha E, Montenegro H, et al. Guideline for the management of feline sporotrichosis caused by Sporothrix brasiliensis and literature revision. Braz J Microbiol Publ Braz Soc Microbiol. 2021;52:107–24.

    Article  Google Scholar 

  66. de Lima Barros MB, Schubach AO, de Vasconcellos Carvalhaes de Oliveira R, Martins EB, Teixeira JL, Wanke B. Treatment of cutaneous sporotrichosis with itraconazole--study of 645 patients. Clin Infect Dis Off Publ Infect Dis Soc Am. 2011;52:e200–206.

  67. Sivagnanam S, Bannan AM, Chen SC-A, Ralph AP. Sporotrichosis (Sporothrix schenckii infection) in the New South Wales mid-north coast, 2000–2010. Med J Aust. 2012;196:588–90.

    Article  PubMed  Google Scholar 

  68. Tang MM, Tang JJ, Gill P, Chang CC, Baba R. Cutaneous sporotrichosis: a six-year review of 19 cases in a tertiary referral center in Malaysia. Int J Dermatol. 2012;51:702–8.

    Article  PubMed  Google Scholar 

  69. Schubach TMP, Schubach A, Okamoto T, et al. Canine sporotrichosis in Rio de Janeiro, Brazil: clinical presentation, laboratory diagnosis and therapeutic response in 44 cases (1998–2003). Med Mycol. 2006;44:87–92.

    Article  PubMed  Google Scholar 

  70. de Souza EW, Borba C de M, Pereira SA, et al. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. Sci Rep. 2018;8:9074.

  71. Orofino-Costa R, de Macedo PM, Rodrigues AM, Bernardes-Engemann AR. Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. An Bras Dermatol. 2017;92:606–20.

    Article  PubMed  PubMed Central  Google Scholar 

  72. Rodrigues AM, Della Terra PP, Gremião ID, Pereira SA, Orofino-Costa R, de Camargo ZP. The threat of emerging and re-emerging pathogenic Sporothrix species. Mycopathologia. 2020;185:813–42.

    Article  PubMed  Google Scholar 

  73. Vettorato R, Heidrich D, Fraga F, Ribeiro AC, Pagani DM, Timotheo C, Amaro TG, Vettorato G, Scroferneker ML. Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo: case report. Med Mycol Case Rep. 2018;19:18–20.

    Article  PubMed  Google Scholar 

  74. Fischman Gompertz O, Rodrigues AM, Fernandes GF, Bentubo HDL, de Camargo ZP, Petri V. Atypical clinical presentation of sporotrichosis caused by Sporothrix globosa resistant to itraconazole. Am J Trop Med Hyg. 2016;94:1218–22.

    Article  PubMed  Google Scholar 

  75. Gremião I, Schubach T, Pereira S, Rodrigues A, Honse C, Barros M. Treatment of refractory feline sporotrichosis with a combination of intralesional amphotericin B and oral itraconazole. Aust Vet J. 2011;89:346–51.

    Article  PubMed  Google Scholar 

  76. da Rocha RFDB, Schubach TMP, Pereira SA, Dos Reis ÉG, Carvalho BW, Gremião IDF. Refractory feline sporotrichosis treated with itraconazole combined with potassium iodide. J Small Anim Pract. 2018;59:720–1.

    Article  PubMed  Google Scholar 

  77. Guterres KA, de Matos CB, Osório LDG, Schuch ID, Cleff MB. The use of (1–3) β-glucan along with itraconazole against canine refractory sporotrichosis. Mycopathologia. 2014;177:217–21.

    PubMed  CAS  Google Scholar 

  78. Bernardes-Engemann AR, Tomki GF, Rabello VB de S, Almeida-Silva F, Freitas DFS, Gutierrez-Galhardo MC, Almeida-Paes R, Zancopé-Oliveira RM. Sporotrichosis caused by non-wild type Sporothrix brasiliensis strains. Front Cell Infect Microbiol. 2022;12:893501.

  79. Morris-Jones R, Youngchim S, Gomez BL, Aisen P, Hay RJ, Nosanchuk JD, Casadevall A, Hamilton AJ. Synthesis of melanin-like pigments by Sporothrix schenckii in vitro and during mammalian infection. Infect Immun. 2003;71:4026–33.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  80. Teixeira MM, Almeida-Paes R, Bernardes-Engemann AR, et al. Single nucleotide polymorphisms and chromosomal copy number variation may impact the Sporothrix brasiliensis antifungal susceptibility and sporotrichosis clinical outcomes. Fungal Genet Biol FG B. 2022;163: 103743.

    Article  PubMed  CAS  Google Scholar 

  81. Brilhante RS, Pereira VS, Oliveira JS, et al. Pentamidine inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents. Future Microbiol. 2018;13:1129–40.

    Article  PubMed  CAS  Google Scholar 

  82. Brilhante RS, Pereira VS, Oliveira JS, et al. Terpinen-4-ol inhibits the growth of Sporothrix schenckii complex and exhibits synergism with antifungal agents. Future Microbiol. 2019;14:1221–33.

    Article  PubMed  CAS  Google Scholar 

  83. Garcia Ferreira P, Pereira Borba-Santos L, Noronha LL, DeckmanNicoletti C, de Sá Haddad Queiroz M, de Carvalho da Silva F, Rozental S, Omena Futuro D, Francisco Ferreira V. Synthesis, stability studies, and antifungal evaluation of substituted α- and β-2,3-dihydrofuranaphthoquinones against Sporothrix brasiliensis and Sporothrix schenckii. Mol Basel Switz. 2019;24:930.

  84. Waller SB, Cleff MB, de Mattos CB, et al. In vivo protection of the marjoram (Origanum majorana Linn.) essential oil in the cutaneous sporotrichosis by Sporothrix brasiliensis. Nat Prod Res. 2021;35:2977–81.

    Article  PubMed  CAS  Google Scholar 

  85. Almeida-Silva F, Bernardes-Engemann AR, Bérenger ALR, da Silva VP, Figueiredo MR, Freitas DFS. In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis. Mem Inst Oswaldo Cruz. 2022;117: e220063.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  86. Artunduaga Bonilla JJ, Honorato L, Haranahalli K, et al. Antifungal activity of acylhydrazone derivatives against Sporothrix spp. Antimicrob Agents Chemother. 2021;65:e02593–20, AAC.02593–20.

  87. Artunduaga Bonilla JJ, Honorato L, Guimarães AJ, Miranda K, Nimrichter L. Silver chitosan nanocomposites are effective to combat sporotrichosis. Front Nanotechnol. 2022;4.

  88. Liu S, Zamith-Miranda D, Almeida-Paes R, da Silva LBR, Nacharaju P, Nosanchuk JD. Nitric oxide-loaded nano- and microparticle platforms serving as potential new antifungal therapeutics. Fungal Biol. 2023;127(7–8):1224–30. https://doi.org/10.1016/j.funbio.2023.01.007.

    Article  PubMed  CAS  Google Scholar 

  89. Borba-Santos LP, Barreto TL, Vila T, et al. In vitro and in vivo antifungal activity of buparvaquone against Sporothrix brasiliensis. Antimicrob Agents Chemother. 2021;65: e0069921.

    Article  PubMed  Google Scholar 

  90. Borba-Santos LP, Nucci M, Ferreira-Pereira A, Rozental S. Anti-Sporothrix activity of ibuprofen combined with antifungal. Braz J Microbiol Publ Braz Soc Microbiol. 2021;52:101–6.

    Article  CAS  Google Scholar 

  91. Asquith CRM, Machado ACS, de Miranda LHM, Konstantinova LS, Almeida-Paes R, Rakitin OA, Pereira SA. Synthesis and identification of pentathiepin-based inhibitors of Sporothrix brasiliensis. Antibiotics. 2019;8:249.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  92. Mathias LDS, Almeida JCDA, Passoni LC, Gossani CMD, Taveira GB, Gomes VM, Vieira-Da-Motta O. Antifungal activity of silver salts of Keggin-type heteropolyacids against Sporothrix spp. J Microbiol Biotechnol. 2020;30:540–51.

    Article  PubMed  CAS  Google Scholar 

  93. Borba-Santos LP, Vila T, Rozental S. Identification of two potential inhibitors of Sporothrix brasiliensis and Sporothrix schenckii in the Pathogen Box collection. PLoS ONE. 2020;15: e0240658.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  94. Borba-Santos LP, Nicoletti CD, Vila T, et al. A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms. Braz J Microbiol Publ Braz Soc Microbiol. 2022;53:749–58.

    Article  CAS  Google Scholar 

  95. Cabañes FJ. Sporotrichosis in Brazil: animals+humans=one health. Rev Iberoam Micol. 2020;37:73–4.

    Article  PubMed  Google Scholar 

  96. Wilfert L, Brown MJF, Doublet V. OneHealth implications of infectious diseases of wild and managed bees. J Invertebr Pathol. 2021;186: 107506.

    Article  PubMed  Google Scholar 

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Funding

AFV and DCJ were supported by grants from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001); AFV was also supported by NIH AI165204. LN, JJAB, and SF were supported by grants from Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). LN and SF were also supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). JDN and DZM were supported in part by NIH R21 AI124797, NIH AI165204, and DOD OR200187.

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Authors and Affiliations

  1. Laboratório de Glicobiologia de Eucariotos, Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, 21941-902, Brazil

    Alessandro F. Valdez, Jhon Jhamilton Artunduaga Bonilla & Leonardo Nimrichter

  2. Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA

    Alessandro F. Valdez, Daniel Zamith-Miranda & Joshua D. Nosanchuk

  3. Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, 21941-170, Brazil

    Dario Corrêa-Junior & Susana Frases

  4. Rede Micologia RJ, FAPERJ, Rio de Janeiro, RJ, 21941-902, Brazil

    Susana Frases, Rodrigo Almeida-Paes & Leonardo Nimrichter

  5. Laboratório de Pesquisa Clínica Em Dermatologia Infecciosa, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21040-360, Brazil

    Dayvison Francis Saraiva Freitas

  6. Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21040-360, Brazil

    Rodrigo Almeida-Paes

Authors
  1. Alessandro F. Valdez
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  2. Dario Corrêa-Junior
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  3. Jhon Jhamilton Artunduaga Bonilla
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  4. Daniel Zamith-Miranda
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  5. Susana Frases
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  6. Dayvison Francis Saraiva Freitas
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  7. Rodrigo Almeida-Paes
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  8. Leonardo Nimrichter
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  9. Joshua D. Nosanchuk
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Contributions

AFV, DCJ, JJAB, DZM, SF, DFSF, and RAP wrote the main manuscript text. AF, JAB, and LN prepared Table 1 and Fig. 1. JDN and LN were responsible for conceptualization. All authors reviewed the manuscript.

Corresponding author

Correspondence to Joshua D. Nosanchuk.

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Valdez, A.F., Corrêa-Junior, D., Bonilla, J.J.A. et al. A Review on Sporotrichosis and the Emergence of Sporothrix brasiliensis as a Pathogen. Curr Trop Med Rep 10, 252–261 (2023). https://doi.org/10.1007/s40475-023-00297-6

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